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10.1016/j.athoracsur.2011.07.048
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Pascual Figal, Domingo A. | - |
dc.contributor.author | Garrido, Iris P | - |
dc.contributor.author | Blanco, Rosa | - |
dc.contributor.author | Minguela, Alfredo | - |
dc.contributor.author | Lax Pérez, Antonio Manuel | - |
dc.contributor.author | Ordoñez Llanos, Jordi | - |
dc.contributor.author | Bayes Genis, Antoni | - |
dc.contributor.author | Valdes, Mariano | - |
dc.contributor.author | Moore, Stephanie | - |
dc.contributor.author | Januzzi, James L | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Medicina | es |
dc.date.accessioned | 2024-01-23T12:03:22Z | - |
dc.date.available | 2024-01-23T12:03:22Z | - |
dc.date.issued | 2011-12 | - |
dc.identifier.citation | Ann Thorac Surg. 2011 Dec;92(6):2118-24.doi: 10.1016/j.athoracsur.2011.07.048. | es |
dc.identifier.issn | 0003-4975 | - |
dc.identifier.uri | http://hdl.handle.net/10201/137572 | - |
dc.description | ©2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in The Annals of Thoracic Surgery. To access the final edited and published work see https://doi.org/10.1016/j.athoracsur.2011.07.048 | es |
dc.description.abstract | Background: Soluble ST2 (sST2), an interleukin (IL)-1 receptor family member, has a role in immunologic tolerance and has also emerged as a biomarker of cardiac stretch and remodeling. The sST2 role in heart transplantation is still unknown. Methods: From the heart transplantation population at our institution (n = 74), we selected a subset of 26 patients who had an acute rejection episode in the first year after transplantation (35%; 52 ± 14 years; 76% men). Endomyocardial biopsy (EMB) results obtained at the time of the first rejection episode represented the rejection cohort (n = 26). Each patient served as a control to himself or herself, with EMB without rejection obtained before and after the rejection episode (n = 52). All laboratory measurements and blood samples were obtained at the time of EMB. Results: sST2 concentrations rose significantly in the context of acute rejection (130 [60 to 238] versus 51 ng/mL [28 to 80]; p = 0.002). Tertile analyses of sST2 concentrations revealed a graded association with rejection (p = 0.002) and repeated measurement analyses showed that sST2 concentrations were significantly modulated by the presence of rejection (p = 0.001). In receiver operator characteristic (ROC) analysis, sST2 had an area under the curve (AUC) of 0.72; the optimal cutoff point was 68 ng/mL (positive predictive value of 53%, negative predictive value of 83%), which predicted acute cellular rejection (odds ratio [OR] 4.9; 95% confidence interval [CI], 1.7 to 14.5; p = 0.004). The addition of sST2 values to those for the N-terminal pro B-type natriuretic peptide (NT-proBNP) resulted in a significant improvement on the integrated discrimination index (IDI) for rejection (relative improvement of 24%; p = 0.021). Conclusions: sST2 concentrations are modulated by the presence of acute rejection and provide complementary predictive ability to NT-proBNP for the biochemical identification of rejection. | es |
dc.format | application/pdf | es |
dc.format.extent | 7 | es |
dc.language | eng | es |
dc.relation | This work was supported by Red Nacional de Investigación en Insuficiencia Cardiaca (REDINSCOR) (RD06/0003), Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain. Dr Januzzi is supported in part by the Balson Cardiac Scholar Fund. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Soluble ST2 is a marker for acute cardiac allograft rejection | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1016/j.athoracsur.2011.07.048 | - |
Aparece en las colecciones: | Artículos: Medicina |
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Soluble ST2 Is a Marker for Acute Cardiac Allograft Rejection.pdf | 229,6 kB | Adobe PDF | ![]() Visualizar/Abrir |
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