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Título: | Composition of marsupial zona pellucida: a molecular and phylogenetic approach |
Fecha de publicación: | 2017 |
Cita bibliográfica: | Reproduction, Fertility and Development |
Palabras clave: | Evolution Fertilisation Oocyte Sperm–egg interaction |
Resumen: | The zona pellucida (ZP) is an extracellular matrix that surrounds mammalian oocytes. In eutherians it is formed from three or four proteins (ZP1, ZP2, ZP3, ZP4). In the few marsupials that have been studied, however, only three of these have been characterised (ZP2, ZP3, ZP4). Nevertheless, the composition in marsupials may be more complex, since a duplication of the ZP3 gene was recently described in one species. The aim of this work was to elucidate the ZP composition in marsupials and relate it to the evolution of the ZP gene family. For that, an in silico and molecular analysis was undertaken, focusing on two South American species (gray short-tailed opossum and common opossum) and five Australian species (brushtail possum, koala, Bennett’s wallaby, Tammar wallaby and Tasmanian devil). This analysis identified the presence of ZP1 mRNA and mRNA from two or three paralogues of ZP3 in marsupials. Furthermore, evidence for ZP1 and ZP4 pseudogenes in the South American subfamily Didelphinae and for ZP3 pseudogenes in two marsupials is provided. In conclusion, two different composition models are proposed for marsupials: a model with four proteins (ZP1, ZP2 and ZP3 (two copies)) for the South American species and a model with six proteins (ZP1, ZP2, ZP3 (three copies) and ZP4) for the Australasian species |
Autor/es principal/es: | Moros-Nicolás, C. Chevret, P. Izquierdo-Rico, M.J. Holt, W.V. Esteban-Dían, D. López-Béjar, M. Martínez-Nevado, E. Nilsson, M.A. Ballesta, J. Avilés, M. |
Facultad/Departamentos/Servicios: | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Biología Celular e Histología |
URI: | http://hdl.handle.net/10201/137521 |
DOI: | https://doi.org/10.1071/RD16519 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 13 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Descripción: | ©2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Reproduction, Fertility and Development. To access the final edited and published work see https://doi.org/10.1071/RD16519 |
Aparece en las colecciones: | Artículos: Biología Celular e Histología |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Proofs marsupialZP_ACCEPTED.pdf | 1,83 MB | Adobe PDF | Visualizar/Abrir |
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