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Título: The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate
Fecha de publicación: 10-ene-2009
Editorial: WILEY
Cita bibliográfica: Pigment Cell & Melanoma Research. Volumen 22I. nº5. Páginas 588-600
ISSN: 1755-1471
Palabras clave: Melanoma
Resumen: Although methotrexate (MTX) is an effective drug for several types of cancer, it is not active against melanoma. Experiments following methotrexate treatment indicated a reduced accumulation of the drug in the cytosolic compartment in melanoma cells, suggesting that the mechanisms that control the transport and retention of this drug could be altered in melanoma. For this reason, we analyzed the presence and function of folate receptor-alpha (FR alpha) in melanoma cells. In this study, we have identified the presence of FR alpha in normal and pathological melanocytes and demonstrated that MTX is preferentially transported through this receptor in melanoma cells. FR alpha-induced endocytic transport of MTX, together with drug melanosomal sequestration and cellular exportation, ensures reduced accumulation of this cytotoxic compound in intracellular compartments. The critical role of FR alpha in this mechanism of resistance and the therapeutic consequences of these findings are also discussed.
Autor/es principal/es: Sánchez del Campo Ferrer, Luis
Montenegro Arce, María Fernanda
Cabezas Herrera, Juan
Rodríguez López, José Neptuno
Facultad/Departamentos/Servicios: Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular A
Versión del editor: https://doi.org/10.1111/j.1755-148X.2009.00586.x
URI: http://hdl.handle.net/10201/136892
DOI: https://doi.org/10.1111/j.1755-148X.2009.00586.x
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 28
Derechos: info:eu-repo/semantics/openAccess
Descripción: This is the peer reviewed version of the following article: [Sánchez-del-Campo L, Montenegro MF, Cabezas-Herrera J, Rodríguez-López JN. The critical role of alpha-folate receptor in the resistance of melanoma to methotrexate. Pigment Cell Melanoma Res. 2009 Oct;22(5):588-600. doi: 10.1111/j.1755-148X.2009.00586.x. Epub 2009 Jun 2.], which has been published in final form at [https://doi.org/10.1111/j.1755-148X.2009.00586.x]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
©2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Pigment Cell & Melanoma Research. To access the final edited and published work see https://doi.org/10.1111/j.1755-148X.2009.00586.x
Aparece en las colecciones:Artículos: Bioquímica y Biología Molecular "A"

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