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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Sánchez del Campo Ferrer, Luis | - |
dc.contributor.author | Otón Vidal, Francisco | - |
dc.contributor.author | Tárraga Tomás, Alberto | - |
dc.contributor.author | Cabezas Herrera, Juan | - |
dc.contributor.author | Chazarra Parres, Soledad | - |
dc.contributor.author | Rodríguez López, José Neptuno | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Bioquímica y Biología Molecular A | es |
dc.date.accessioned | 2023-12-22T11:07:33Z | - |
dc.date.available | 2023-12-22T11:07:33Z | - |
dc.date.issued | 2008-04-10 | - |
dc.identifier.citation | Journal of Medicinal Chemistry. Volumen 51. nº7. Paginas 2018-2026 | es |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.issn | 1520-4804 | - |
dc.identifier.uri | http://hdl.handle.net/10201/136888 | - |
dc.description | ©2008. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Journal of Medicinal Chemistry. To access the final edited and published work see https://doi.org/10.1021/jm701346h | es |
dc.description.abstract | Despite presenting bioavailability problems, tea catechins have emerged as promising chemopreventive agents because of their observed efficacy in various animal models. To improve the stability and cellular absorption of tea polyphenols, we developed a new catechin-derived compound, 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin (TMECG), which has shown significant antiproliferative activity against several cancer cell lines, especially melanoma. The presence of methoxy groups in its ester-bound gaily] moiety drastically decreased its antioxidant and prooxidant properties without affecting its cell-antiproliferative effects, and the data indicated that the 3-gallyl moiety was essential for its biological activity. As regards its action mechanism, we demonstrated that TMECG binds efficiently to human dihydrofolate reductase and down-regulates folate cycle gene expression in melanoma cells. Disruption of the folate cycle by TMECG is a plausible explanation for its observed biological effects and suggests that, like other antifolate compounds, TMECG could be of clinical value in cancer therapy. | es |
dc.format | application/pdf | es |
dc.format.extent | 38 | es |
dc.language | eng | es |
dc.publisher | AMER CHEMICAL SOC | es |
dc.relation | Ámbito del proyecto: Nacional y regional. Agencia financiadora: Ministerio de Educación y Ciencia y Fundación Séneca (CARM) Código o número del acuerdo de subvención: SAF2006-07040-C02-01, SAF2006-07040-C02-02, 02970/PI/05 | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Tea | es |
dc.subject | Acido fólico | es |
dc.subject | Epigallocatechin-3-gallate | es |
dc.subject | Antioxidant natural products | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales::57 - Biología::577 - Bioquímica. Biología molecular. Biofísica | es |
dc.title | Synthesis and Biological Activity of a 3,4,5-Trimethoxybenzoyl Ester Analogue of Epicatechin-3-gallate | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.1021/jm701346h | - |
Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "A" |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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JMEDCHEM-TMECG 2008.pdf | 491,06 kB | Adobe PDF | Visualizar/Abrir |
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