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| Título: | The protein acetyltransferase PatZ from Escherichia coli is regulated by autoacetylation-induced oligomerization |
| Fecha de publicación: | 2015 |
| Cita bibliográfica: | Journal of Biological Chemistry (JBC) |
| ISSN: | 0021-9258 |
| Palabras clave: | Acetyltransferase Post-translational modification (PTM) Acetyl coenzyme A (acetyl-CoA) Escherichia coli (E. coli) Lysine acetylation Autoacetylation Oligomerization Protein acetyltransferase (PatZ or YfiQ) |
| Resumen: | Background: PatZ is the main Escherichia coli acetyltransferase and control acetyl-CoA synthetase (Acs) activity. Results: The kinetic and structural PatZ oligomer characteristics were determined. Conclusion: PatZ is a stable tetramer and forms an active octamer by autoacetylation to increase its stability. Significance: PTMs by acetylation have structural and functional roles in the cell. |
| Autor/es principal/es: | De Diego Puente, Teresa Gallego Jara, Julia Castaño Cerezo, Sara Bernal Sanchez, Vicente Manjón Rubio, Antonio Cánovas Diaz, Manuel Fernández Espín, Vanesa García de la Torre, José |
| URI: | http://hdl.handle.net/10201/136586 |
| DOI: | http://www.jbc.org/cgi/doi/10.1074/jbc.M115.649806 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 33 |
| Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 International |
| Descripción: | ©2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Journal of Biological Chemistry (JBC). To access the final edited and published work see http://www.jbc.org/cgi/doi/10.1074/jbc.M115.649806 |
| Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| J.Biol.Che..5.pdf | 1,93 MB | Adobe PDF |  Visualizar/Abrir |
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