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| Título: | The Nutrition in Early Life and Asthma (NELA) birth cohortstudy: Rationale, design, and methods |
| Cita bibliográfica: | Paediatric and Perinatal Epidemiology, 2021;00:1–15. |
| ISSN: | Print: 0269-5022 Electronic: 1365-3016 |
| Palabras clave: | Diet Allergy Mother-child cohort |
| Autor/es principal/es: | Morales Bartolome, Eva Alcantara Lopez, Maria V. Cabezas Herrera, Juan De Diego, Teresa Hernandez Caselles, Trinidad Jimenez Guerrero, Pedro Larque Daza, Elvira Lopez Soler, Concepción Martinez Gracia, Carmen Martinez Torres, Antonela Martin-orozco Santiago, Elena Mendiola Olivares, Jaime Nieto Diaz, Anibal Noguera, Jose A. Perez Fernandez, Virginia Prieto Sanchez, M. Teresa Salvador Garcia, Carmen Sanchez Solis De Querol, Manuel Santaella Pascual, Marina Sola Martinez, Rosa A. Torres Cantero, Alberto Yagüe, Genoveva Zornoza Moreno, Matilde Garcia-marcos Alvarez, Luis |
| Versión del editor: | https://onlinelibrary.wiley.com/journal/13653016 |
| URI: | http://hdl.handle.net/10201/136573 |
| DOI: | https://doi.org/10.1111/ppe.12826 |
| Tipo de documento: | info:eu-repo/semantics/article |
| Número páginas / Extensión: | 15 |
| Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
| Descripción: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in
any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
© 2021 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd. Background: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests. Objectives: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility. Population: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19–22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the “Virgen de la Arrixaca” University Clinical Hospital over a 36-month period, from March 2015 to April 2018. Design: Prospective, population-based, maternal-child, birth cohort study. Methods: Questionnaires on exposures and outcome variables were administered to mothers at 20–24 gestation week; 32–36 gestation week; and delivery. Children were |
| Aparece en las colecciones: | Artículos: Bioquímica y Biología Molecular "B" e Inmunología |
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