1. Digitum: Repositorio Institucional de la Universidad de Murcia
  2. Revistas y Congresos
  3. Revistas
  4. Histology and histopathology
  5. Vol.39, nº1 (2024)
Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-613

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dc.contributor.authorLi, Lihua-
dc.contributor.authorChen, Wenchao-
dc.contributor.authorWu, Gang-
dc.contributor.authorSun, Peichun-
dc.date.accessioned2023-12-07T09:58:51Z-
dc.date.available2023-12-07T09:58:51Z-
dc.date.issued2024-
dc.identifier.citationHistology and Histopathology Vol. 39, nº1 (2024)es
dc.identifier.issn0213-3911-
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/136485-
dc.description.abstractColorectal cancer is one of the most common cancers with high morbidity and mortality. Effective treatments to improve the prognosis are still lacking. The results of online analysis tools showed that OCT1 and LDHA were highly expressed in colorectal cancer, and the high expression of OCT1 was associated with poor prognosis. Immunofluorescence demonstrated that OCT1 and LDHA co-localized in colorectal cancer cells. In colorectal cancer cells, OCT1 and LDHA were upregulated by OCT1 overexpression, but downregulated by OCT1 knockdown. OCT1 overexpression promoted cell migration. OCT1 or LDHA knockdown inhibited the migration, and the downregulation of LDHA restored the promoting effect of OCT1 overexpression. OCT1 upregulation increased the levels of HK2, GLUT1 and LDHA proteins in colorectal cancer cells. Consequently, OCT1 promoted the migration of colorectal cancer cells by upregulating LDHA.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectColorectal canceres
dc.subjectOCT1es
dc.subjectLDHAes
dc.subjectMigrationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleOCT1 regulates the migration of colorectal cancer cells by acting on LDHAes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.14670/HH-18-613-
Aparece en las colecciones:Vol.39, nº1 (2024)

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