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https://doi.org/10.14670/HH-18-598
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Título: | Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº12 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Colorectal cancer Circ_0071803 MiR-3305p/MAPK1 Proliferation Metastasis |
Resumen: | Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide. A lack of effective targeted therapies against CRC makes the treatment challenging. Here, we report a circular RNA (circRNA), has_circ_0071803, functioning as an oncogene in CRC. Circ_0071803 was upregulated in CRC tissues and cell lines, and its expression levels were inversely correlated with the prognosis and survival rate of patients with CRC. Circ_0071803 knockdown suppressed cell proliferation, migration, and invasion in CRC. Moreover, we found that circ_0071803 sponged miR-330-5p, thereby upregulating mitogen-activated protein kinase 1 (MAPK1) in CRC cells. The suppression of cell activities by circ_0071803 knockdown were rescued by miR-330-5p inhibition or MAPK1 overexpression. Collectively, our findings elucidate that circ_0071803 promotes CRC progression by regulating the miR-330-5p/MAPK1 pathway, providing potential therapeutic targets for designing effective targeted treatments |
Autor/es principal/es: | Huang, Liyong Dou, Guangjian Lu, Jiajun Chen, Zhiheng Wang, Jiayi |
URI: | http://hdl.handle.net/10201/136287 |
DOI: | https://doi.org/10.14670/HH-18-598 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38,nº12 (2023) |
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4f6b01ce-dad4-44fe-91b3-27eadca8edaa-8.pdf | 8,67 MB | Adobe PDF | Visualizar/Abrir |
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