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https://doi.org/10.1007/s00429-016-1326-6
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Cardeña-Núñez, Sheila | - |
dc.contributor.author | Sánchez-Guardado, Luis Óscar | - |
dc.contributor.author | Corral-San-Miguel, Rubén | - |
dc.contributor.author | Rodríguez-Gallardo, Lucía | - |
dc.contributor.author | Marín, Faustino | - |
dc.contributor.author | Puelles, Luis | - |
dc.contributor.author | Aroca, Pilar | - |
dc.contributor.author | Hidalgo-Sánchez, Matías | - |
dc.contributor.other | Facultades, Departamentos, Servicios y Escuelas::Departamentos de la UMU::Anatomía Humana y Psicobiología | es |
dc.date.accessioned | 2023-11-24T08:43:07Z | - |
dc.date.available | 2023-11-24T08:43:07Z | - |
dc.date.issued | 2016-10-25 | - |
dc.identifier.citation | Brain Struct Funct (2017) 222:2071–2092 | - |
dc.identifier.issn | Print: 1863-2653 | - |
dc.identifier.issn | Electronic: 1863-2661 | - |
dc.identifier.uri | http://hdl.handle.net/10201/136004 | - |
dc.description | © 2016 Springer-Verlag Berlin Heidelberg.This document is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Brain Structure and Function. To access the final edited and published work see https://doi.org/10.1007/s00429-016-1326-6 | es |
dc.description.abstract | The vertebrate inner ear is a complex three-dimensional sensorial structure with auditory and vestibular functions. The molecular patterning of the developing otic epithelium creates various positional identities, consequently leading to the stereotyped specification of each neurosensory and non-sensory element of the membranous labyrinth. The Iroquois (Iro/Irx) genes, clustered in two groups (A: Irx1, Irx2, and Irx4; and B: Irx3, Irx5, and Irx6), encode for transcriptional factors involved directly in numerous patterning processes of embryonic tissues in many phyla. This work presents a detailed study of the expression patterns of these six Irx genes during chick inner ear development, paying particular attention to the axial specification of the otic anlagen. The Irx genes seem to play different roles at different embryonic periods. At the otic vesicle stage (HH18), all the genes of each cluster are expressed identically. Both clusters A and B seem involved in the specification of the lateral and posterior portions of the otic anlagen. Cluster B seems to regulate a larger area than cluster A, including the presumptive territory of the endolymphatic apparatus. Both clusters seem also to be involved in neurogenic events. At stages HH24/25-HH27, combinations of IrxA and IrxB genes participate in the specification of most sensory patches and some non-sensory components of the otic epithelium. At stage HH34, the six Irx genes show divergent patterns of expression, leading to the final specification of the membranous labyrinth, as well as to cell differentiation. | es |
dc.format | application/pdf | es |
dc.format.extent | 59 | es |
dc.language | eng | es |
dc.publisher | Laszlo Zaborsky - Springer | es |
dc.relation | This work was supported by: grant sponsor: Spanish Ministry of Science, BFU2010- 19461; grant sponsor: Junta de Extremadura, GR10152 (to M.H.-S.); grant sponsor: MICINN, BFU2006-15530-C02/BFI (to L.R.-G.); grant sponsor: Spanish Ministry of Science, BFU2005-09378-C02-01; grant sponsor: MICINN, BFU2014-57516P; grant sponsor: SENECA Foundation, 19904/GERM/15 (to L.P.); grant sponsor: MICINN, BFU2006-15530-C01/BFI (to P.A); grant sponsor: Junta-de-Extremadura predoctoral fellowship, PRE/08031 (to L.-O.S.-G.). The 3A10 antibody developed by T.M. Jessell and J. Dodd was obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD and maintained by The University of Iowa, Department of Biology, Iowa City, IA, USA. | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Otocyst; | es |
dc.subject | Otic vesicle; | es |
dc.subject | Otic specification; | es |
dc.subject | Sensory patch; | es |
dc.subject | Acoustic-vestibular ganglion | es |
dc.subject.other | CDU::5 - Ciencias puras y naturales | es |
dc.title | Expression Patterns of Irx Genes in the Developing Chick Inner Ear | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.1007/s00429-016-1326-6 | - |
Aparece en las colecciones: | Artículos: Anatomía Humana y Psicobiología |
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