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https://doi.org/10.14670/HH-18-628
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Título: | Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº11 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Rheumatoid arthritis Crosstalk Synovial macrophages Synovial fibroblasts |
Resumen: | Rheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of joints. Abnormally activated cells such as synovial macrophages and synovial fibroblasts induce RA pathogenesis and ultimately joint destruction. Since macrophages can change their own characteristics depending on the microenvironmental condition, it has been suggested that activation and remission of RA are regulated by crosstalk between synovial macrophages and other cells. Moreover, recent findings of heterogeneity of synovial macrophages and fibroblasts support the idea that complex interactions regulate RA from its onset to remission. Importantly, an understanding of the intercellular crosstalk in RA is far from complete. Here, we summarize the molecular mechanisms underlying the pathological development of RA with particular reference to the crosstalk between synovial macrophages and fibroblasts. |
Autor/es principal/es: | Saeki, Noritaka Ima, Yuuki |
URI: | http://hdl.handle.net/10201/135729 |
DOI: | https://doi.org/10.14670/HH-18-628 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38,nº11 (2023) |
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616d70fd-054e-47cf-ba40-a671e812bd8c(1).pdf | 1,6 MB | Adobe PDF | Visualizar/Abrir |
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