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https://doi.org/10.14670/HH-18-605
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Título: | Women with psychotic episodes during pregnancy show increased markers of placental damage with Tenney-Parker changes |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.38, nº10, (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Psychosis Mental disorders Pregnancy Placenta Maternofetal well-being Histopathology |
Resumen: | y. Psychosis is a hazardous and functionally disruptive psychiatric condition which may affect women in pregnancy, entailing negative consequences for maternofetal well-being. The precise pathophysiological basis and consequences of a psychotic episode in pregnancy remain to be further elucidated. The placenta is a pivotal tissue with many functions in the gestational period, critically influencing the fate and development of pregnancy. Although detrimental alterations have been observed in women undergoing severe psychiatric disorders in pregnancy, there are little studies evaluating the consequences of suffering from a psychotic episode in the placental tissue In this work, we have evaluated the histopathological consequences of a first episode of psychosis in pregnancy (FE-PW; N=22) and compare them with healthy pregnant women (HC-PW; N=20) by using histological, immunohistochemical and gene expression techniques. Our results define that the placental tissue of FE-PW display an increase in the number of placental villi, bridges, syncytial knots and syncytial knots/villi. Besides, we have also observed an enhanced gene and protein expression in FE-PW of the hypoxic marker HIF-1α, together with the apoptotic markers BAX and Bcl-2. To our knowledge, this is the first study demonstrating significant histopathological changes in the placenta of women suffering a new-onset psychotic episode in pregnancy. Further studies should be aimed at deepening the knowledge about the pernicious effects of psychosis in the maternofetal tissues, as well as the potential implications of these alterations. |
Autor/es principal/es: | Ortega, Miguel A. Fraile Martínez, Oscar García Montero, Cielo Rodriguez Martín, Sonia Funes Moñux, Rosa M. Pekarek, Leonel Bravo, Coral Leon Luis, Juan A. De Saez, Miguel A. Guijarro, Luis G. Lahera, Guillermo Monserrat, Jorge Rodriguez Jimenez, Roberto Saz, Jose V. Buján, Julia García Honduvilla, Natalio Álvarez Mon, Melchor Alvarez Mon, Miguel Angel |
URI: | http://hdl.handle.net/10201/134364 |
DOI: | https://doi.org/10.14670/HH-18-605 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38,nº10 (2023) |
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Ortega-38-1109-1118-2023.pdf | 6,84 MB | Adobe PDF | ![]() Visualizar/Abrir |
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