1. Digitum: Repositorio Institucional de la Universidad de Murcia
  2. Revistas y Congresos
  3. Revistas
  4. Histology and histopathology
  5. Vol.38, nº9 (2023)
Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-599

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dc.contributor.authorWang, Yujing-
dc.contributor.authorYue, Shuling-
dc.contributor.authorCai, Feng-
dc.contributor.authorZhu, Wen-
dc.contributor.authorZhong, Yuxiang-
dc.contributor.authorChen, Juanjuan-
dc.contributor.authorLi, Chunyun-
dc.date.accessioned2023-09-13T08:32:21Z-
dc.date.available2023-09-13T08:32:21Z-
dc.date.issued2023-
dc.identifier.citationHistology and Histopathology Vol. 38, nº9 (2023)es
dc.identifier.issn0213-3911-
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/133844-
dc.description.abstractDiabetic nephropathy (DN) has become one of the major fatal factors in diabetic patients. The aim of this study was to elucidate the function and mechanism by which berberine exerts renoprotective effects in DN. In this work, we first demonstrated that urinary iron concentration, serum ferritin and hepcidin levels were increased and total antioxidant capacity was significantly decreased in DN rats, while these changes could be partially reversed by berberine treatment. Berberine treatment also alleviated DN-induced changes in the expression of proteins involved in iron transport or iron uptake. In addition, berberine treatment also partially blocked the expression of renal fibrosis markers induced by DN, including MMP2, MMP9, TIMP3, β-arrestin-1, and TGF-β1. In conclusion, the results of this study suggest that berberine may exert renoprotective effects by ameliorating iron overload and oxidative stress and reducing DNes
dc.formatapplication/pdfes
dc.format.extent8es
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectDiabetic nephropathyes
dc.subjectIron overloades
dc.subjectOxidative stresses
dc.subjectBerberinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleTreatment of berberine alleviates diabetic nephropathy by reducing iron overload and inhibiting oxidative stresses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.14670/HH-18-599-
Aparece en las colecciones:Vol.38, nº9 (2023)

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