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Título: | 3D model of the maternal-fetal interface: challenges, recent advances and beyond |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº8 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculares |
Palabras clave: | 3D in vitro model Embryo Endometrium Endometrial receptivity Organoids Embryoids |
Resumen: | Embryo implantation is a complex and highly coordinated process that involves an intricate network of factors establishing intimate contact at the maternal-fetal interface. Knowledge of the human implantation process is compromised by both ethical issues, which do not allow the study of this process in vivo, and by the accuracy and reproducibility of in vitro models of human endometrium. Effective and reliable embryo implantation models are, therefore, necessary to mimic the molecular event cascade that occurs in vivo. 3D models are considered a new step to foster precision medicine and an advanced tool for the study of endometrial biology, endometrium associated diseases and to understand the complex mechanisms surrounding endometrium-embryo crosstalk. In this review we explore the various methods by which 3D cultures of endometrium and trophoblast can be created, exploring targets and applications of these in vitro models. |
Autor/es principal/es: | Passaponti, Sofia Luongo, Francesca Paola Ietta, Francesca Luddi, Alice Piombon, Paola |
URI: | http://hdl.handle.net/10201/133707 |
DOI: | https://doi.org/10.14670/HH-18-584 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 15 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38, nº8 (2023) |
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c1a3becd-86e8-46cb-908a-bbfb749de984.pdf | 4,32 MB | Adobe PDF | Visualizar/Abrir |
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