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dc.contributor.authorSalas Alvarez, Jesús-
dc.contributor.authorCampos Martínez, Francisco Javier-
dc.contributor.authorCamacho Ramírez, Alonso-
dc.contributor.authorMontero Peña, Cristian-
dc.contributor.authorRibelles García, Antonio-
dc.contributor.authorPérez Arana, Gonzalo M.-
dc.contributor.authorPrada Oliveira, J. Arturo-
dc.date.accessioned2023-09-06T10:29:06Z-
dc.date.available2023-09-06T10:29:06Z-
dc.date.issued2023-
dc.identifier.citationHistology and Histopathology, Vol.38, nº7, (2023)es
dc.identifier.urihttp://hdl.handle.net/10201/133665-
dc.description.abstractThe population with obesity has increased at an alarming rate during this century. Bariatric surgery has been demonstrated to be a good method to control weight and, most importantly, associated comorbidities, such as type 2 diabetes mellitus or high blood pressure. The reason why this happens even before losing significant weight remains unclear. Many authors believe that incretins play a main role, triggering special functions of the digestive tract. In reports, these hypotheses are known as foregut and hindgut theories. Initially, the theories were mutually exclusive; additionally, many other propositions have been analysed, according to different surgical techniques (e.g., bile acids and specific enterohormonal components). To elucidate the participation of the ileum, we developed a surgical technique to study the rapid response to nutrients in the ileum. Our goal was to study the stress functional test and histological changes in the pancreas that may explain the variations in glycaemic homeostasis in our rat model. After the oral glucose tolerance test, the experimental group presented an increased insulin release response with conserved glycaemia. We report an increasing beta-cell mass in the experimental group (+11.87 mg vs. +9.65 mg, respectively), while alpha-cell mass was not different. Based on transcription factors, the pathways that were increased were the proliferation process (as the number of PCNA-positive cells in the experimental group versus sham (+12.06 vs. +6.2 PCNA+ cells/mm2)) and transdifferentiation (ARX; +2.67 ARX+ cells/mm2 in the experimental group vs. +2.04 ARX+ cells/mm2 in the controls). We report the consequences of the rapid arrival of nonprocessed nutrients to the ileum on the endocrine cellular pancreas. The ileum could be a principal effector in the enterohormonal axis, which conditions endocrine pancreas cellularityes
dc.formatapplication/pdfes
dc.format.extent9es
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBeta-cell masses
dc.subjectPancreases
dc.subjectIleumes
dc.subjectType 2 diabetes mellituses
dc.subjectIncretinses
dc.subjectCellular differentiationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleBeta-cell mass adaptation to ileum nutrient flow. An experimental modeles
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/ 10.14670/HH-18-563-
Aparece en las colecciones:Vol.38, nº7 (2023)

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