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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Wang, Feng | - |
dc.contributor.author | Zhao, Miao | - |
dc.contributor.author | Jiang, Yuehong | - |
dc.contributor.author | Xia, Silong | - |
dc.contributor.author | Sun, Dapeng | - |
dc.contributor.author | Zhou, Dahong | - |
dc.contributor.author | Dong, Zipu | - |
dc.date.accessioned | 2023-05-24T11:37:20Z | - |
dc.date.available | 2023-05-24T11:37:20Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Histology and Histopathology Vol. 38, nº6 (2023) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/131387 | - |
dc.description.abstract | Background. Long noncoding RNA ubiquitin-conjugating enzyme E2 R2 antisense RNA 1 (UBE2R2-AS1) has been recently reported to participate in the progression of tumors, including glioma and liver cancer. However, the roles of UBE2R2-AS1 in prostate cancer (PC) remained poorly understood. Methods. The expression of UBE2R2-AS1 was determined in tumor tissues and paired adjacent tissues from PC patients using quantitative reverse transcription PCR analysis. Correlation between UBE2R2-AS1 expression and clinicopathological parameters and overall survival were investigated by Chi-square test and Kaplan-Meier method analysis. The in vitro experiments, including CCK-8 assay, colony formation, flow cytometry and transwell assay were performed to investigate the functional role of UBE2R2-AS1 knockdown or overexpression on PC cell lines (PC-3 and DU145). Related protein expression levels were measured by western blot analysis. Results. Our data showed that UBE2R2-AS1 expression was significantly upregulated in PC tissues compared with that in adjacent tissues. The high levels of UBE2R2-AS1 were associated with high Gleason score, advanced clinical T stage, lymph node metastasis and poor prognosis. Knockdown of UBE2R2-AS1 suppressed cell proliferation, migration and invasion, induced cell cycle G0/G1 arrest and apoptosis in PC cells, along with decreased expression of PCNA, CDK4, Cyclin D1, Bcl-2, N-cadherin and Vimentin, and increased E-cadherin expression. Overexpression of UBE12R2-AS1 obtained the opposite results in PC cells. Conclusions. Our findings suggest that UBE2R2- AS1 might be a potential diagnostic and/or therapeutic target in PC. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Prostate cancer | es |
dc.subject | UBE2R2-AS1 | es |
dc.subject | Prognosis | es |
dc.subject | Proliferation | es |
dc.subject | Migration | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | LncRNA UBE2R2-AS1, as prognostic marker, promotes cell proliferation and EMT in prostate cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-505 | - |
Aparece en las colecciones: | Vol.38, nº6 (2023) |
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Wang-38-637-645-2023.pdf | 5,65 MB | Adobe PDF | Visualizar/Abrir |
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