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Título: | Earliest histopathological changes in COVID-19 pneumonia with comprehensive gene expression analyses: A case series study |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº6 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | COVID-19 Diffuse alveolar damage Earliest histopathological change |
Resumen: | Aims. In COVID-19 pneumonia, early detection and appropriate treatment are essential to prevent severe exacerbation. Therefore, it is important to understand the initiating events of COVID-19 pneumonia. However, at present, the literature about early stage disease has been very limited. Here, we investigated the earliest histopathological changes and gene expression profiles associated with COVID-19 pneumonia. Methods and Results. We carefully examined 25 autopsied cases with different clinical courses. Dilation of capillaries and edematous thickening of the alveolar septa were found even in areas that macroscopically looked almost normal. Pneumocytes, histocytes/ macrophages, and vascular endothelial cells were immunohistochemically positive for tissue factor, which is an important early responder to tissue injuries. Comprehensive gene expression analyses revealed that those lesions presented differential profiles compared to those of control lungs and were associated with a significant upregulation of the lysosomal pathway. Conclusions. Alveolar capillary dilation and edematous thickening may be the earliest histopathological change detected in COVID-19 pneumonia. Intensive investigations of such lesions may lead to an understanding of the initiating event of not only COVID-19 pneumonia but also of general diffuse alveolar damage. |
Autor/es principal/es: | Okudela, Koji Hayashi, Hiroyuki Yoshimura, Yukihiro Sasaki, Hiroaki Miyata, Nobuyuki Iwashita, Hiromichi Kataoka, Toshiaki Matsumura, Mai Mitsui, Hideaki Hatayama, Yasuyoshi Yamashiro, Tsuneo Ryo, Akihide Tachikawa, Natsuo |
URI: | http://hdl.handle.net/10201/131386 |
DOI: | https://doi.org/10.14670/HH-18-557 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 14 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38, nº6 (2023) |
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Okudela-38-623-636-2023.pdf | 15,69 MB | Adobe PDF | Visualizar/Abrir |
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