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Título: | MiR-29c-3p represses gastric cancer development via modulating MEST |
Fecha de publicación: | 2023 |
Cita bibliográfica: | Histology and Histopathology Vol. 38, nº5 (2023) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Gastric cancer miR-29c-3p MEST Proliferation Invasion |
Resumen: | Gastric cancer (GC) triggers a great number of deaths worldwide. Although great efforts have been made in treating this cancer, GC patients’ survival rate remains unsatisfactory. An increasing amount of evidence indicates that miR-29c-3p inhibits cancer progression. However, the mechanism of miR-29c-3p in GC remains to be fully defined. Hence, this work aimed to analyze the underlying mechanism of miR-29c-3p in GC. Outcomes showed marked downregulation of miR29c-3p in GC tissue and cell lines. Functional experiments exhibited that miR-29c-3p repressed GC cell malignant behaviors. Moreover, bioinformatics analysis and dual-luciferase reporter gene detection indicated that MEST was targeted by miR-29c-3p. Rescue assay further proved that MEST participated in functions of miR-29c-3p in GC. To sum up, miR-29c3p/MEST signaling pathway suppressed formation of malignant phenotypes of GC, and targeting the signaling pathway may be a new method for treating GC. |
Autor/es principal/es: | Li, Honghai Lv, Jieqing Wang, Jindao Wang, Haifeng Luo, Liang |
URI: | http://hdl.handle.net/10201/130614 |
DOI: | https://doi.org/10.14670/HH-18-537 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 9 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38, nº5 (2023) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Li-38-549-557-2023.pdf | 4,94 MB | Adobe PDF | Visualizar/Abrir |
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