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Título: | Role of insulin signaling and its associated signaling in glomerulus for diabetic kidney disease |
Fecha de publicación: | 2023 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.38, nº5, (2023) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Diabetic kidney disease (DKD) Insulin signaling Insulin receptor substrate 1 (IRS1) Vascular endothelial growth factor (VEGF) Pyruvate kinase M2 (PKM2) |
Resumen: | The number of patients with diabetic kidney disease (DKD) has been rising significantly over the last several decades and is one of the most frequent causes of chronic kidney disease (CKD) in the United States. Hyperglycemia accelerates development of DKD, a direct result of increased intracellular glucose availability. Two large clinical studies, the Diabetes Control and Complications Trial in type 1 diabetes and the United Kingdom Prospective Diabetes Study in type 2 diabetes showed that intensive glycemic control delayed the onset and the progression of DKD. On the other hand, it is reported that glycemic control alone is not sufficient to control DKD progression. Recent data support that insulin signaling and its associated signaling contribute significantly to preserve glomerular function. However, little is known about the key regulators of insulin signaling in glomerular component cells. In this review, we summarize the novel knowledge regarding the reno-protective effects of insulin signaling or its associated signaling in glomerular constituent cells on DKD. |
Autor/es principal/es: | Mima, Akira Yasuzawa, Toshinori |
URI: | http://hdl.handle.net/10201/130503 |
DOI: | https://doi.org/10.14670/HH-18-543 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 6 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.38, nº5 (2023) |
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Mima-38-487-492-2023.pdf | 463,67 kB | Adobe PDF | Visualizar/Abrir |
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