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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Nakayama, Shizuhide | - |
dc.contributor.author | Nishio, Jun | - |
dc.contributor.author | Aoki, Mikiko | - |
dc.contributor.author | Koga, Kaori | - |
dc.contributor.author | Nabeshima, Kazuki | - |
dc.contributor.author | Yamamoto, Takuaki | - |
dc.date.accessioned | 2023-03-08T16:06:39Z | - |
dc.date.available | 2023-03-08T16:06:39Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Histology and Histopathology Vol. 38, nº1 (2023) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/129208 | - |
dc.description.abstract | Myxofibrosarcoma (MFS) is a fibroblastic/ myofibroblastic neoplasm with a variably myxoid stroma. Histologically, MFS shows a wide spectrum of cellularity, pleomorphism and proliferative activity. Because of its variable morphology and lack of discriminatory markers, MFS can be difficult to distinguish from some benign soft-tissue tumors, especially nodular fasciitis (NF). Glucose transporter 1 (GLUT-1) is expressed in a variety of malignant mesenchymal tumors. In the current study, we evaluated GLUT-1 expression to determine its value in distinguishing MFS from NF. Tissue specimens from 14 MFS cases and 16 NF cases were sectioned and stained for GLUT-1 using immunohistochemistry. The percentage of GLUT-1-positive cells was scored as follows: 0 (no staining), 1+ (1-19%), 2+ (20-50%) and 3+ (>50%). Samples with a score of 1+ were defined as GLUT1-expressing samples. GLUT-1 expression was seen in all 14 MFS cases, whereas only 6 NF cases (37.5%) were positive for GLUT-1 and were scored 1+. Notably, 2-3+ GLUT-1 expression was found in 86% of MFS cases and 0% of NF cases. Our results indicate that GLUT-1 is a highly sensitive immunohistochemical marker for MFS and may be useful for the differential diagnosis of MFS and NF. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Myxofibrosarcoma | es |
dc.subject | Nodular fasciitis | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | GLUT-1 expression is helpful to distinguish myxofibrosarcoma from nodular fasciitis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/ 10.14670/HH-18-490 | - |
Aparece en las colecciones: | Vol.38, nº1 (2023) |
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Nakayama-38-47-51-2023.pdf | 2,35 MB | Adobe PDF | Visualizar/Abrir |
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