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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Liu, Xiaoqin | - |
dc.contributor.author | Song, Lijuan | - |
dc.contributor.author | Yu, Jiezhong | - |
dc.contributor.author | Huang, Fang | - |
dc.contributor.author | Li, Yanhua | - |
dc.contributor.author | Ma, Cungen | - |
dc.date.accessioned | 2023-02-17T10:09:04Z | - |
dc.date.available | 2023-02-17T10:09:04Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Histology and Histopathology Vol. 37, nº6 (2022) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/128555 | - |
dc.description.abstract | Mitochondria are energy-producing organelles, and neurons are high energy consumption cells. Therefore, mitochondrial dysfunction is a critical factor in neurodegenerative processes. Mitochondrial division inhibitor-1 (Mdivi-1) is a small chemical inhibitor of mitochondrial division dynamin, which plays multiple roles in mitochondrial dynamics, mitochondrial autophagy, ATP production, the immune response, and Ca2+ homeostasis. Mdivi-1 inhibition of excessive mitochondrial fission exerted cytoprotective effects in neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS). Mdivi-1 changed the mRNA expression of the electron transport chain (ETC) and reduced Ca2+ overload against neuronal injury. Elucidation of the molecular mechanism of Mdivi-1 in neurodegenerative diseases will help evaluate its therapeutic potential and promote its application in clinical studies. The present article focused on the multiple effects of Mdivi-1 on mitochondrial function and its potential therapeutic effects in neurodegenerative diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Mdivi-1 | es |
dc.subject | Mitochondrial dysfunction | es |
dc.subject | Neurodegenerative diseases | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Mdivi-1: a promising drug and its underlying mechanisms in the treatment of neurodegenerative diseases | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/ 10.14670/HH-18-443 | - |
Aparece en las colecciones: | Vol.37, nº6 (2022) |
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Liu-37-505-512-2022.pdf | 338,59 kB | Adobe PDF | Visualizar/Abrir |
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