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https://doi.org/10.14670/HH-18-416
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Chen, Dongdong Chen | - |
dc.contributor.author | Fan, Jiaxing | - |
dc.contributor.author | Li, Xianduo | - |
dc.contributor.author | Jiao, Zongshuai | - |
dc.contributor.author | Tang, Guanbao | - |
dc.contributor.author | Guo, Xuewen | - |
dc.contributor.author | Chen, Hao | - |
dc.contributor.author | Wang, Jianning | - |
dc.contributor.author | Men, Tongyi | - |
dc.date.accessioned | 2023-02-17T08:14:27Z | - |
dc.date.available | 2023-02-17T08:14:27Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | Histology and Histopathology Vol. 37, nº5 (2022) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/128543 | - |
dc.description.abstract | Background. Prostate cancer (PC) is the second leading cause of cancer-related death among men worldwide. Downregulation of miR-485-3p has been revealed to participate in the tumorigenesis and progression of many types of cancer. However, the clinical and biological role of miR-485-3p in PC remains largely unknown. Methods. The expression of miR-485-3p was analyzed in the published databases and detected in our clinical samples and cell lines by RT-qPCR assay. CCK8, transwell invasion and migration, and colony formation assays were performed to investigate the biological function of miR-485-3p. Bioinformatical analysis, RIP, western blotting and luciferase reporter assays were carried out to explore the downstream mechanism of miR-485-3p. Results. The level of miR-485-3p was downregulated in PC tissues, particularly in primary PC tissues with metastasis relative to normal prostate tissues. miR-485-3p downregulation was positively correlated with poor disease-free and overall survival in patients with PC. Functionally, miR-485-3p overexpression dramatically suppressed the proliferation, migration and invasion ability of PC cells in vitro. Mechanistically, miR-485-3p overexpression suppressed the activity of TGF-β signaling by targeting TGFBR2 to play tumor-suppressive roles in PC progression. Conclusion. Our study reports the miR-485- 3p/TGFBR2/ TGF-β signaling axis in tumor development of PC, suggesting miR-485-3p may be a potential target to develop therapeutic strategies against PC. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | miR-485-3p | es |
dc.subject | Prostate cancer | es |
dc.subject | Proliferation | es |
dc.subject | Migration | es |
dc.subject | Invasion | es |
dc.subject | TGFBR2 | es |
dc.subject | TGF-β signaling | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Downregulation of miR-485-3p promotes proliferation, migration and invasion in prostate cancer through activation of TGF-β signaling | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-416 | - |
Aparece en las colecciones: | Vol.37, nº5 (2022) |
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Chen-37-423-430-2022.pdf | 6,23 MB | Adobe PDF | ![]() Visualizar/Abrir |
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