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https://doi.org/ 10.14670/HH-18-404
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Título: | Adenosine deaminase, not immune to a mechanistic rethink in central nervous system disorders? |
Fecha de publicación: | 2022 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 37, nº3 (2022) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Adenosine deaminase Central nervous system Pathology Severe combined immunodeficiency Amyotrophic lateral sclerosis |
Resumen: | Adenosine deaminase (ADA) is a purine metabolism enzyme that catalyses the breakdown of adenosine and deoxyadenosine. The enzyme is important in several cellular processes, including the innate immune response and cellular differentiation, and it is also an important enzyme for the maintenance of brain homeostasis, in part due to its regulation of adenosine. Aberrant regulation of ADA enzyme activity has been linked to several neurodegenerative diseases and diseases that can result in neurological impairment. However, the mechanisms behind altered ADA regulation and how this leads to the development of neurological dysfunction are poorly characterised. This review summarises the current research on ADA and its role and regulation in disease pathology, with a focus on the central nervous system (CNS) and the neurodegenerative disease, amyotrophic lateral sclerosis (ALS) |
Autor/es principal/es: | Hall, Benjamin George, Jonathan G. Allen, Scott P. |
URI: | http://hdl.handle.net/10201/128325 |
DOI: | https://doi.org/ 10.14670/HH-18-404 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 24 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.37, nº3 (2022) |
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Fichero | Descripción | Tamaño | Formato | |
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Hall-37-189-212-2022.pdf | 4,48 MB | Adobe PDF | ![]() Visualizar/Abrir |
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