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https://doi.org/10.14670/HH-18-396
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Título: | ATG7 immunohistochemical expression in malignant pleural mesothelioma. A preliminary report |
Fecha de publicación: | 2021 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 36, nº12 (2021) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Malignant Pleural Mesothelioma Autophagy ATG7 Immunohistochemistry Asbestiform fibers Ex vivo study |
Resumen: | Literature evidence has demonstrated a high incidence of asbestos-related malignant pleural mesothelioma (MPM) in a Sicilian town (Biancavilla, Italy), where fluoro-edenite (FE) fibers were discovered some decades ago. As ATG7 immunohistochemical analysis has been ascribed as a prognostic tool of improved survival, we decided to investigate, in MPM patients, exposed and not exposed to FE fibers, the immunohistochemical expression of this autophagyrelated protein named ATG7. We analyzed the correlation between ATG7 immunohistochemical level and clinicopathological parameters. Twenty MPM tissue samples, from patients with available clinical and follow-up data, were included in paraffin and processed for immunohistochemistry. The immunohistochemical results confirmed activation of the autophagic process in MPM. Densitometric and morphometric expressions of ATG7 were significantly increased in MPMs when compared to the control tissues. A significant association of a high level of ATG7 with increased survival was demonstrated, with a mean overall survival (OS) of 12.5 months for patients with high expression vs. a mean OS of 4.5 months for patients with low ATG7 expression. In addition, a significant correlation between ATG7 expression and the survival time of MPM patients was observed. This study represents a starting point to hypothesize the prognostic role of ATG7 which could be a reliable prognostic indicator in MPM |
Autor/es principal/es: | Rapisarda, Venerando Broggi, Giuseppe Caltabiano, Rosario Lombardo, Claudia Castorina, Sergio Trovato, Angela Ledda, Caterina Filetti, Veronica Loreto, Carla |
URI: | http://hdl.handle.net/10201/128132 |
DOI: | https://doi.org/10.14670/HH-18-396 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.36,nº12 (2021) |
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Rapisarda-36-1301-1308-2021.pdf | 1,9 MB | Adobe PDF | Visualizar/Abrir |
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