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Título: Relationship of human papillomavirus with seborrheic keratosis of the female genital tract - a case-series and literature review
Fecha de publicación: 2021
Editorial: Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Cita bibliográfica: Histology and Histopathology Vol. 36, nº12 (2021)
ISSN: 0213-3911
1699-5848
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Vulvar neoplasms
Viral skin diseases
Seborrheic keratosis
Human papillomavirus DNA tests
Cyclin-dependent kinase inhibitor p16
Viral oncogene proteins
Laser capture microdissection
Resumen: Seborrheic keratoses (SKs) are benign lesions of uncertain etiology, which can develop in both genital and extra-genital locations. For genital SKs there has been conjecture about the pathogenic role of human papillomavirus (HPV), in view of the frequent association of this virus with genital lesions. In light of the potential consequences on patient management, we investigated the relationship between HPV and SKs of the female genital tract (FGT). For this, we evaluated the current evidence on this relationship by performing an in-depth review of the literature. Furthermore, to add to the evidence on this association, we investigated the presence of HPV in a series of vulvar SKs (n=15), using a novel multimodal approach. This involved whole tissue section-polymerase chain reaction (WTS-PCR) using SPF10-DEIA-LiPA25 for HPV detection and genotyping. In addition, immunohistochemistry (IHC) was performed with cellular biomarkers p16 and MIB-1, and viral biomarker E4, to augment HPV-testing. Finally, laser-capture microdissection-PCR (LCM-PCR) was performed to locate HPV to specific lesional cells, and to rule out incidental detection of resident HPV with WTS-PCR. Our findings from the literature review as well as the case-series are presented.
Autor/es principal/es: Dasgupta, Shatavisha
Eersel, Rachel van
Morrel, Beth
Munckhof, Henk A.M. van den
Geus, Vera A. de
Hoeven, Nick M.A. van der
Sandt, Miekel M. van de
Piso-Jozwiak, Marta
Quint, Wim G.V.
Avoort, Irene A.M. van der
Koljenović, Senada
Ewing-Graham, Patricia C.
Kemenade, Folkert J. van
URI: http://hdl.handle.net/10201/128103
DOI: https://doi.org/10.14670/HH-18-357
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 10
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.36,nº12 (2021)

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