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https://doi.org/10.14670/HH-18-297
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Título: | Extracellular vesicles derived from mesenchymal stem cells: A platform that can be engineered |
Fecha de publicación: | 2021 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 36, nº6 (2021) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Mesenchymal stem cells Extracellular vesicles Engineering Targeting Translational Medicine Loading |
Resumen: | y. Mesenchymal stem cells play an important role in tissue damage and repair. This role is mainly due to a paracrine mechanism, and extracellular vesicles (EVs) are an important part of the paracrine function. EVs play a vital role in many aspects of cell homeostasis, physiology, and pathology, and EVs can be used as clinical biomarkers, vaccines, or drug delivery vehicles. A large number of studies have shown that EVs derived from mesenchymal stem cells (MSC-EVs) play an important role in the treatment of various diseases. However, the problems of low production, low retention rate, and poor targeting of MSC-EVs are obstacles to current clinical applications. The engineering transformation of MSC-EVs can make up for those shortcomings, thereby improving treatment efficiency. This review summarizes the latest research progress of MSC-EV direct and indirect engineering transformation from the aspects of improving MSC-EV retention rate, yield, targeting, and MSC-EV visualization research, and proposes some feasible MSC-EV engineering methods of transformation. |
Autor/es principal/es: | Qin, Bo Zhang, Qi Chen, Dan Yu, Hai-yang Luo, Ai-xiang Suo, Liang-peng Cai, Yan Cai, De-yang Luo, Jia Huang, Ju-fang Xiong, Kun |
URI: | http://hdl.handle.net/10201/127348 |
DOI: | https://doi.org/10.14670/HH-18-297 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.36, nº6 (2021) |
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Fichero | Descripción | Tamaño | Formato | |
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Qin-36-615-632-2021.pdf | 18,97 MB | Adobe PDF | Visualizar/Abrir |
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