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https://doi.org/10.14670/HH-18-322
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Título: | Defective expression of the peroxisome regulators PPARα receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder |
Fecha de publicación: | 2021 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 36, nº5 (2021) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Chronic venous disorder CVeD Vascular homeostasis PPAR TFEB Senescence p16 |
Resumen: | The pathogenesis of chronic venous disorder (CVeD) remains partially understood. A marked wall remodeling has been shown with potential accelerated tissue senescence. We have investigated the expression of peroxisome proliferator-activated receptor (PPAR) isoforms transcription factor EB (TFEB) as regulatory molecules of cellular homeostasis and makers of peroxisomal and lysosomal biogenesis. We have also quantified p16 expression as a cellular senescence marker. In specimens of maior safena vein from 35 CVeD and 27 healthy venous controls (HV), we studied the expression of PPAR-α, PPAR-β/δ, PPAR-γ, TFEB and p16 by RT-qPCR and immunohistochemical techniques. We have demonstrated a reduced gene and protein expression of the PPAR-α and PPAR-β/δ isoform as well as that of TFEB in the venous wall of CVeD patients, suggesting an altered peroxisomal and lysosomal biogenesis associated with an increased cellular senescence shown by increased p16 expression |
Autor/es principal/es: | Ortega, Miguel A Fraile-Martínez, Oscar Pekarek, Leonel Alvarez-Mon, Miguel A. Asúnsolo, Ángel Sanchez-Trujillo, Lara Coca, Santiago Buján, Julia Álvarez-Mon, Melchor GarcíaHonduvilla, Natalio Sain, Felipe |
URI: | http://hdl.handle.net/10201/127205 |
DOI: | https://doi.org/10.14670/HH-18-322 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 12 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.36, nº5 (2021) |
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Ortega-36-547-558-2021.pdf | 20,32 MB | Adobe PDF | Visualizar/Abrir |
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