Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-311

Título: Exposure to second-hand cigarette smoke exacerbates the progression of osteoarthritis in a surgical induced murine model
Fecha de publicación: 2021
Editorial: Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Cita bibliográfica: Histology and Histopathology Vol. 36, nº3 (2021)
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Second-hand smoke
Resumen: Osteoarthritis (OA), formerly understood to be a result of passive wear, is now known to be associated with chronic inflammation. Cigarette smoking promotes systemic inflammation and has been implicated in increased joint OA incidence in some studies, though the recent observational data on the association are contradictory. We hypothesize that second-hand smoke (SHS) treatment will increase the incidence of OA in a mouse model that has been subjected to a surgical destabilization of the medial meniscus (DMM). To test this hypothesis, we applied either SHS treatment or room air (RA) to mice for 28 days post-DMM surgery. Histopathology findings indicated that the knees of SHS mice exhibited more severe OA than their control counterparts. Increased expression of matrix metalloprotease-13 (MMP-13), an important extracellular protease known to degrade articular cartilage, and nuclear factor kappa-light-chainenhancer of activated B cells (NF-κB), an intracellular effector of inflammatory pathways, were observed in the SHS group. These findings provide greater understanding and evidence for a detrimental role of cigarette smoke on OA progression and systemic inflammation.
Autor/es principal/es: Rose, Brandon J.
Weyand, Jeffery A.
Liu, Brady
Smith, Jacob F.
Perez, Brian R.
Clark, J. Christian
Goodman, Michael
Budge, Kelsey M. Hirschi
Eggett, Dennis L.
Arroyo, Juan A.
Reynolds, Paul R.
Kooyman, David L.
URI: http://hdl.handle.net/10201/127016
DOI: https://doi.org/10.14670/HH-18-311
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 7
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.36, nº3 (2021)

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