Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-304

Registro completo de metadatos
Campo DCValorLengua/Idioma
dc.contributor.authorWang, Hejing-
dc.contributor.authorLi, Yanmeng-
dc.contributor.authorZhou, Donghu-
dc.contributor.authorLi, Xiaojin-
dc.contributor.authorJia, Siyu-
dc.contributor.authorQi, Saiping-
dc.contributor.authorHuang, Jian-
dc.date.accessioned2022-12-23T09:47:36Z-
dc.date.available2022-12-23T09:47:36Z-
dc.date.issued2021-
dc.identifier.citationHistology and Histopathology Vol. 36, nº2 (2021)es
dc.identifier.issn0213-3911-
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/126784-
dc.description.abstractColorectal cancer (CRC) is common worldwide. Aldehyde dehydrogenase 1B1 (ALDH1B1), a member of the ALDH1 family, serves as a biomarker for cancer stem cells. We hypothesized that ALDH1B1 expression is associated with colorectal tumors. Immunohistochemistry was used to detect ALDH1B1 expression across a commercial colorectal tissue microarray. The signal intensities of the positively stained tissues were expressed using the mean integrated optical density (mean IOD). We also analyzed ALDH1B1 mRNA expression in the Oncomine database. The associations between ALDH1B1 expression and CRC stage and prognosis were then evaluated using the web-based tools, GEPIA and UALCAN. Analysis of the tissue microarray revealed that the expression of ALDH1B1 was significantly higher in colorectal adenomas and colorectal adenocarcinoma (IOD/area values = 0.117±0.070 and 0.168±0.0168, respectively) compared with normal and cancer-adjacent tissues (IOD/area values = 0.051±0.028 and 0.068±0.053). For samples collected in the hospital, ALDH1B1 was highly expressed in the adenoma (IOD/area = 0.103±0.054) and CRC (IOD/area = 0.116±0.059) tissues compared with the cancer-adjacent tissues (IOD/area = 0.066±0.024, p<0.05). The expression of ALDH1B1 in tissues from two resources was not found to be significantly associated with CRC stage. In Oncomine, ALDH1B1 mRNA expression was increased in the colorectal tumor tissues compared with the normal colorectal tissues (p=0.024) and its expression was independent of CRC stage and prognosis (p<0.05). Thus, while the protein and mRNA expression of ALDH1B1 suggests that it is a potential marker of colorectal tumors, its expression is independent of CRC stage and prognosis.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectColorectal canceres
dc.subjectColorectal adenomaes
dc.subjectALDH1B1es
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleAldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors-
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.14670/HH-18-304-
Aparece en las colecciones:Vol.36, nº2 (2021)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Wang-36-183-194-2021.pdf15,47 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons