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https://doi.org/10.14670/HH-18-300
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Título: | Absence of lymphatic vessels in non-functioning bleb capsules of glaucoma drainage devices |
Fecha de publicación: | 2020 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 35, nº12 (2020) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Glaucoma drainage devices Bleb capsule Lymphatic tissue Baerveldt Lyve-1 Podoplanin |
Resumen: | Purpose. To evaluate the presence and appearance of blood and lymphatic vessels in nonfunctioning bleb capsules of glaucoma drainage devices (GDD). Materials and methods. Non-functioning (n=14) GDD-bleb capsules of 12 patients were analyzed by immunohistochemistry for blood vessels (CD31, vascular endothelium), lymphatic vessels (lymphatic vessel endothelial hyaluronan receptor-1 [LYVE-1] and podoplanin) and macrophages (CD68). Results. CD31+++ blood vessels and CD68+ macrophages were detected in the outer layer of all specimens. LYVE-1 immunoreactivity was registered in single non-endothelial cells in 8 out of 14 (57%) bleb capsule specimens. Podoplanin-immunoreactivity was detected in all cases, located in cells and profiles of the collagen tissue network of the outer and/or the inner capsule layer. However, a colocalization of LYVE-1 and podoplanin as evidence for lymphatic vessels was not detected. Conclusions. We demonstrate the presence of bloodvessels but absence of lymphatic vessels in nonfunctioning bleb capsules after GDD-implantation. While the absence of lymphatic vessels might indicate a possible reason for drainage device failure, this needs to be confirmed in upcoming studies, including animal experiments. |
Autor/es principal/es: | Siggel, Robert Schroedl, Falk Dietlein, Thomas Koch, Konrad R. Platzl, Christian Kaser-Eichberger, Alexandra Cursiefen, Claus Heindl, Ludwig M. |
URI: | http://hdl.handle.net/10201/126728 |
DOI: | https://doi.org/10.14670/HH-18-300 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.35,nº12 (2020) |
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Siggel-35-1521-1531-2020.pdf | 16,04 MB | Adobe PDF | Visualizar/Abrir |
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