Por favor, use este identificador para citar o enlazar este ítem: 10.14670/HH-18-270

Título: Fragmentation of the Golgi complex of dopaminergic neurons in human substantia nigra: New cytopathological findings in Parkinson's disease
Fecha de publicación: 2021
Editorial: Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, Vol.36, nº1, (2021)
ISSN: 1699-5848
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Golgi complex
Parkinson’s disease
Dopaminergic neurons
Substantia nigra
Membrane traffic
Resumen: Fragmentation of the Golgi ribbon is a common feature of Parkinson’s disease and other neurodegenerative diseases. This alteration could be the consequence of the anterograde and retrograde transport imbalance, α-synuclein aggregates, and/or cytoskeleton alterations. Most information on this process has been obtained from cellular and animal experimental models, and as such, there is little information available on human tissue. If the information on human tissue was available, it may help to understand the cytopathological mechanisms of this disease. In the present study, we analyzed the morphological characteristics of the Golgi complex of dopaminergic neurons in human samples of substantia nigra of control and Parkinson’s disease patients. We measured the expression levels of putative molecules involved in Golgi fragmentation, including αsynuclein, tubulin, and Golgi-associated regulatory and structural proteins. We show that, as a consequence of the disease, the Golgi complex is fragmented into small stacks without vesiculation. We found that only a limited number of regulatory proteins are altered. Rab1, a small GTPase regulating endoplasmic reticulum-to-Golgi transport, is the most dramatically affected, being highly overexpressed in the surviving neurons. We found that the SNARE protein syntaxin 5 forms extracellular aggregates resembling the amyloid plaques characteristic of Alzheimer’s disease. These findings may help to understand the cytopathology of Parkinson’s disease.
Autor/es principal/es: Tomás, Mónica
Martínez Alonso, Emma
Martínez Martínez, Narcisa
Cara Esteban, Mireia
Martínez Menárguez, José A.
URI: http://hdl.handle.net/10201/126166
DOI: 10.14670/HH-18-270
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 14
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.36, nº1 (2021)

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