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https://doi.org/10.14670/HH-18-216
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Zhang, Rongkui | - |
dc.contributor.author | Li, Fuwei | - |
dc.contributor.author | Wang, Yuchong | - |
dc.contributor.author | Yao, Ming | - |
dc.contributor.author | Chi, Changliang | - |
dc.date.accessioned | 2022-11-30T09:40:32Z | - |
dc.date.available | 2022-11-30T09:40:32Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Histology and Histopathology Vol. 35, nº8 (2020) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/126092 | - |
dc.description.abstract | Background. miR-20b is a member of the miR-106a-363 gene cluster located in the mammalian X chromosome, the larger miR-17 family, and the miR-17- 92 and miR-106b-25 gene clusters. Previous studies have indicated that miR-20b may function as oncogene or tumor suppressor in different types of cancers. The present study analyzed the association between miR-20b and clinicopathological characteristics of patients with prostate cancer. Methods. A total of 127 pairs of prostate cancer tissue samples and adjacent prostate tissue samples were collected from April 2013 to March 2018. The associations between miR-20b expression levels and clinicopathological factors were assessed using the χ 2‑test. Survival was estimated using the Kaplan-Meier method, and the differences in survival according to miR-20b expression were compared using the log-rank test. Prognostic values of miR-20b expression and clinical outcomes were evaluated by Cox regression analysis. Results. The relative expression of miR-20b in prostate cancer tissues was significantly higher than that in adjacent noncancerous prostate tissues (P<0.001). miR-20b expression was observed to be significantly associated with Gleason score (P<0.001), lymph node metastasis (P<0.001), and TNM stage (P=0.002). The log-rank test indicated that patients with increased miR- 20b expression experienced poor overall survival (P=0.037). Multivariate Cox regression analysis showed that miR-20b expression level (HR=2.181, 95% CI: 1.772-9.021, P=0.016) was an independent factor in predicting the overall survival of prostate cancer patients. Conclusion. The present study demonstrated that tissue miR-20b expression level could be a promising biomarker of prognosis in prostate cancer. | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | MicroRNA-20b | es |
dc.subject | Multivariate Cox regression analysis | es |
dc.subject | Expression | es |
dc.subject | Prognosis | es |
dc.subject | Prostate cancer | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Prognostic value of microRNA-20b expression level in patients with prostate cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-216 | - |
Aparece en las colecciones: | Vol.35, nº8 (2020) |
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