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https://doi.org/10.14670/HH-18-210
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Título: | Atypical spindle cell/pleomorphic lipomatous tumor |
Fecha de publicación: | 2020 |
Editorial: | Universidad de Murcia, Departamento de Biologia Celular e Histiologia |
Cita bibliográfica: | Histology and Histopathology Vol. 35, nº8 (2020) |
ISSN: | 0213-3911 1699-5848 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Atypical spindle cell/pleomorphic lipomatous tumor Atypical spindle cell lipomatous tumor Atypical pleomorphic lipomatous tumor RB1 MDM2 Liposarcoma Spindle cell/pleomorphic lipoma |
Resumen: | Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently described morphologically low-grade and clinically indolent adipocytic tumor, which will be incorporated as a new tumor entity in the upcoming 5th edition of the WHO Classification of Soft tissue and Bone tumors. Histologically, ASPLTs are characterized by ill-defined tumor margins and the presence of variable proportions of mild-to-moderately atypical spindle cells, adipocytes, lipoblasts, pleomorphic multinucleated cells and a myxoid or collagenous extracellular matrix. ASPLTs can show a wide variety of microscopic appearances and there is histologic overlap with diverse mimics. The diagnosis of ASPLT can therefore be challenging. Molecular studies have shown a consistent absence of MDM2 or CDK4 amplification. On the other hand, deletions or losses of 13q14, including RB1, have been identified in a significant subset of cases. This review provides an overview of the currently known clinical and pathological features of ASPLTs, detailing its most relevant differential diagnoses. |
Autor/es principal/es: | Lecoutere, Evelyne Creytens, David |
URI: | http://hdl.handle.net/10201/126085 |
DOI: | https://doi.org/10.14670/HH-18-210 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.35, nº8 (2020) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Lecoutere-35-769-778-2020.pdf | 5,53 MB | Adobe PDF | Visualizar/Abrir |
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