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dc.contributor.advisorFortoul, Teresa I.-
dc.contributor.authorLópez Valdez, Nelly-
dc.contributor.authorGuerrero Palomo, Gabriela-
dc.contributor.authorRojas-Lemus, Marcela-
dc.contributor.authorBizarro-Nevares, Patricia-
dc.contributor.authorGonzález-Villalva, Adriana-
dc.contributor.authorUstarroz-Cano, Martha-
dc.contributor.authorRivera-Fernández, Norma-
dc.date.accessioned2022-11-21T17:01:47Z-
dc.date.available2022-11-21T17:01:47Z-
dc.date.issued2020-
dc.identifier.citationHistology and Histopathology Vol. 35, nº5 (2020)es
dc.identifier.issn0213-3911-
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/125793-
dc.description.abstractThe Non-Ciliated Bronchiolar Cell (NCBC) is responsible for the defense and maintenance of the bronchiolar epithelium. Several cellular defense mechanisms have been associated with an increase in the secretion of CC16 and changes in the phenotype of the cell; these mechanisms could be linked to tolerance to the damage due to exposure to inhaled Particulate Matter (PM) of the epithelium. These defense mechanisms have not been sufficiently explored. In this article, we studied the response of the NCBC to inhaled vanadium, an element which adheres to PM. This response was measured by the changes in the phenotype of the NCBC and the secretion of CC16 in a mouse model. Mice were exposed in two phases to different vanadium concentrations; 1.56 mg/m 3 in the first phase and 2.57 mg/m3 in the second phase. Mice were sacrificed on the 2nd, 4th, 5th, 6th and 8th weeks. In the second phase, we observed the following: sloughing of the NCBC, hyperplasia and small inflammatory foci remained without changes and that the expression of CC16 was higher in this phase than in phase I. We also observed a change in the phenotype with a slow decrease in both phases. The increase in the secretion of CC16 and the phenotype reversion could be due to the anti- inflammatory activity of CC16. The changes observed in the second phase could be attributed to the tolerance to inhaled vanadium.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectNCBCes
dc.subjectCC16es
dc.subjectVanadiumes
dc.subjectTolerancees
dc.subjectPhenotypees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleThe role of the non-ciliated bronchiolar cell in tolerance to inhaled vanadium of the bronchiolar epitheliumes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.14670/HH-18-165-
Aparece en las colecciones:Vol.35, nº5 (2020)

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