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Título: Microscopic study of chronic Charcot arthropathy foot bones contributes to understanding pathogenesis - a preliminary report.
Fecha de publicación: 2020
Editorial: Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Cita bibliográfica: Histology and Histopathology Vol. 35, nº5 (2020)
ISSN: 0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Histology
Chronic Charcot arthropathy
Lamellar architecture
Trabecular thinning
Resumen: Introduction. Charcot arthropathy (CA) is non-infective, chronic destructive condition affecting the pes architecture of long standing diabetic patients with neuropathy. Even though several theories have emerged to disclose its pathogenesis, inflammatory cytokine induced osteoclastogenesis stands as the chief culprit. Studies on micro-architecture of foot bones of acute stage CA patients, describes mainly destructive phase of bone remodelling. Increased osteoclast cell activity is reported in all studies communicated. No study has to the best of our knowledge detailed the microscopic structure of chronic stage CA foot bones. Aim. To study the microscopic structure of foot bones in patients with chronic CA. Materials and methods. Foot bones were collected from the feet of chronic CA patients (six in number) who underwent corrective foot surgery in the department of Podiatric Surgery of a tertiary care hospital. Control samples were collected from the feet of age matched non-diabetic controls (2 in number). The samples were fixed in formalin, decalcified in 10% nitric acid, processed, sectioned and stained with haematoxylin and eosin. Histopathology and histomorphometry analysis were performed by two different pathologists. Results. Trabeculae of chronic CA foot bones exhibited mainly a lamellar architecture, with reduced number of osteocytes and plenty of empty lacunae. Trabecular connectivity was lost and trabeculae showed considerable thinning. Trabecular osteoids lined by active osteoblast cells was a remarkable observation. Bone area was also considerably reduced in chronic CA foot bones. Conclusion. Chronic stage CA foot bones presented features of both healing and fragile bone. The compromised bone quality may be due to thin and fragmented trabecular structure and reduced cellularity.
Autor/es principal/es: Dharmadas, Salini
Kumar, Harish
Pillay, Minnie
Jojo, Annie
Tessy, P.J.
Mangalanandan, Thacho Sukumaran
Vivek, Lakshmanan
Praveen, Valiyaparambil Pavithran
Bal, Arun
URI: http://hdl.handle.net/10201/125685
DOI: https://doi.org/10.14670/HH-18-162
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 5
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.35, nº5 (2020)

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