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https://doi.org/10.14670/HH-18-189
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Sanguedolce, Francesca | - |
dc.contributor.author | Cormio, Luigi | - |
dc.contributor.author | Carrieri, Giuseppe | - |
dc.contributor.author | Calò, Beppe | - |
dc.contributor.author | Russo, Davide | - |
dc.contributor.author | Menin, Andrea | - |
dc.contributor.author | Pastore, Antonio Luigi | - |
dc.contributor.author | Greco, Francesco | - |
dc.contributor.author | Bozzini, Giorgio | - |
dc.contributor.author | Galfano, Antonio | - |
dc.contributor.author | Pini, Giovannalberto | - |
dc.contributor.author | Porreca, Angelo | - |
dc.contributor.author | Mugavero, Filippo | - |
dc.contributor.author | Falsaperla, Mario | - |
dc.contributor.author | Ceruti, Carlo | - |
dc.contributor.author | Cindolo, Luca | - |
dc.contributor.author | Antonelli, Alessandro | - |
dc.contributor.author | Minervini, Andrea | - |
dc.date.accessioned | 2022-11-17T09:21:23Z | - |
dc.date.available | 2022-11-17T09:21:23Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Histology and Histopathology Vol. 35, nº5 (2020) | es |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.uri | http://hdl.handle.net/10201/125684 | - |
dc.description.abstract | In order to evaluate the potential prognostic/predictive role of androgen receptor (AR) expression in non-muscle-invasive bladder cancer (NMIBC), and whether it may represent a therapeutic target, we conducted a systematic search of the literature using ‘androgen receptor or AR’, ‘testosterone’, ‘bladder cancer’ and ‘non-muscle invasive bladder cancer or NMIBC’ as keywords. Eleven studies met the inclusion/exclusion criteria. No significant association was found between AR status and patients’ gender (p=0.232), tumor size (p=0.975), tumor stage (p=0.237), tumor grade (p=0.444), tumor multicentricity (p=0.397), concomitant CIS (p=0.316) and progression of disease (p=0.397). On the other hand, relative lack of AR expression was significantly correlated to recurrent disease (p=0.001). Evidence for a direct correlation between AR expression and recurrence-free survival of patients with NMIBC indicate ARs as potential markers of BC behavior; moreover, the finding of a role of androgen blockade therapy in improving survival highlights the potential clinical application of this pathway, which deserves to be further explored. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Androgen receptor | es |
dc.subject | Non-muscle-invasive bladder cancer | es |
dc.subject | Immunohistochemistry | es |
dc.subject | Prognosis | es |
dc.subject | Biomarkers | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Role of androgen receptor expression in non-muscle-invasive bladder cancer: a systematic review and meta-analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-189 | - |
Aparece en las colecciones: | Vol.35, nº5 (2020) |
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Fichero | Descripción | Tamaño | Formato | |
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Sanguedolce-35-423-432-2020.pdf | 2,27 MB | Adobe PDF | ![]() Visualizar/Abrir |
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