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dc.contributor.authorJung, Yeon Seung-
dc.contributor.authorChung, Dong Yong-
dc.contributor.authorKim, Eun Jin-
dc.contributor.authorCho, Nam Hoon-
dc.date.accessioned2022-11-02T17:57:48Z-
dc.date.available2022-11-02T17:57:48Z-
dc.date.issued2020-
dc.identifier.citationHistology and Histopathology Vol. 35, nº 2 (2020)es
dc.identifier.issn0213-3911-
dc.identifier.issn1699-5848-
dc.identifier.urihttp://hdl.handle.net/10201/125104-
dc.description.abstractContext. Malakoplakia can be caused by incomplete digestion of Escherichia coli by lysosomes, leading to recurrent urinary tract infections and consequential mass-forming events that mimic tumors. Objectives. By using ultrastructural findings, we aimed to specify the process of phagolysosome to evoke malakoplakia. Design. We observed a series of processes to form a peculiar Michaelis-Gutmann (MG) body in three patients with malakoplakia and compared with xanthogranulomatous pyelonephritis. Results. The ultrastructural findings were realigned according to the sequence of events as pre-phagosomal, phagosomal, and post-phagosomal stages. For the mature MG body, numerous lysosomal aggregates targeting pathogens and subsequent incomplete digestion are prerequisite factors for the pre-phagosomal stage. Scattered lamellated residue is late evidence of the pre- phagosomal stage. Phagosomes can be formed by the fusion of multiple pathogens and multiple lysosomes. We utilized transmission and scanning electron microscopy to speculate on the process of phagolysosomal formation. Conclusion. The recognition of E. coli captured by phagosomes or partially damaged by lysosomal attack within the cell was recorded for the first time. Furthermore, SEM observation was performed on human tissuees
dc.formatapplication/pdfes
dc.format.extent8es
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMalakoplakiaes
dc.subjectMichaelis Gutmann bodyes
dc.subjectE. colies
dc.subjectXanthogranulomatous pyelonephritises
dc.subjectTransmission electron microscopyes
dc.subjectScanning electron microscopees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleUltrastructural evidence of the evolutional process in malakoplakiaes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.14670/HH-18-150-
Aparece en las colecciones:Vol.35, nº2 (2020)

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