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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Umahara, Takahiko | - |
dc.contributor.author | Uchihara, Toshiki | - |
dc.contributor.author | Hirao, Kentaro | - |
dc.contributor.author | Shimizu, Soichiro | - |
dc.contributor.author | Hashimoto, Takao | - |
dc.contributor.author | Akimoto, Jiro | - |
dc.contributor.author | Kohno, Michihiro | - |
dc.contributor.author | Hanyu, Haruo | - |
dc.date.accessioned | 2022-11-02T17:27:03Z | - |
dc.date.available | 2022-11-02T17:27:03Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Histology and Histopathology Vol. 35, nº 2 (2020) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/125068 | - |
dc.description.abstract | The transactivation response DNA binding protein (TARDP) of 43 kDa (TDP-43) is a nuclear protein pivotal in RNA processing. Because phosphorylated (p) TDP-43 has been identified as a component of ubiquitin-positive and tau-negative inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), it is considered to play a major role in neurodegenerative processes. We investigated the immunolocalization of pTDP-43 in atherosclerotic lesions of human carotid and main cerebral arteries. Furthermore, we investigated the co- localization between pTDP-43 and 14-3-3 eta isoform or high mobility group box 1 (HMGB1). pTDP-43 localized in the cytoplasm of many foamy macrophages located in the periphery of lipid-rich necrotic cores, and in the cytoplasm of infiltrated smooth muscle cell-like cells. pTDP-43 co-localized the 14-3-3 eta isoform in carotid plaques. pTDP-43 also co- localized HMGB1. This is the first demonstration of pTDP-43 immunolocalization in human carotid and main cerebral artery plaques. We believe that demonstration of the localization of pTDP-43 in atherosclerotic lesions is important as this may contribute to the establishment of the clinical diagnostic imaging of FTLD and ALS using the pTDP-43 epitope. Moreover, this finding may be useful for further understanding the role of TDP in cell death. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia, Departamento de Biologia Celular e Histiologia | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | TDP-43 | es |
dc.subject | Vascular smooth muscle cells | es |
dc.subject | Macrophages | es |
dc.subject | Atherosclerosis | es |
dc.subject | Carotid artery | es |
dc.subject | Main cerebral arteries | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Frontotemporal dementia-associated protein "phosphorylated TDP-43" localizes to atherosclerotic lesions of human carotid and main cerebral arteries | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | https://doi.org/10.14670/HH-18-140 | - |
Aparece en las colecciones: | Vol.35, nº2 (2020) |
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Umahara-35-159-167-2020.pdf | 17,31 MB | Adobe PDF | Visualizar/Abrir |
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