Por favor, use este identificador para citar o enlazar este ítem: https://doi.org/10.14670/HH-18-116

Título: Immunohistochemical expression and localization of MMP-9, MMP-13, E-Cadherin and Ki-67 in road pavers' skin chronically exposed to bitumen products.
Fecha de publicación: 2019
Editorial: Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Cita bibliográfica: Histology and Histopathology Vol. 34, nº 10 (2019)
ISSN: 0213-3911
1699-5848
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Cancer
Occupational exposure
PAHs
Matrix metalloproteinase
E-cadherin
Ki-67
Workers
Resumen: To investigate the matrix metalloproteinase (MMP)-9, (MMP)-13, E-Cadherin and Ki-67 expressions in road pavers’ skin chronically exposed to bitumen products in order to contribute to a better understanding of the earlier tissue alteration. Skin punch biopsies from 16 daily exposed workers and a control group were studied by immunohistochemistry. Morphometric and densitometric analyses were also conducted. Morphological specimen evaluation of skin of road pavers showed epidermal thinning, flattening and loss of intercellular junction with a decreased expression of E-cadherin confined to the basal skin layer, together with MMP-9 and MMP-13 overexpressions in all epidermis layers, vascular structures and adnexa. No immunohistochemical alteration was reported for Ki-67 vs normal skin. Results from this study show that overexpression of MMP-9 and MMP-13 may represent an early response of the first human barrier to exposure to bitumen products. Regulation of MMPs could be one of the strategies to prevent primary skin disease.
Autor/es principal/es: Loreto, Carla
Lombardo, Claudia
Caltabiano, Rosario
Filetti, Vera
Vitale, Ermanno
Seminara, Danilo
Castorina, Sergio
Fenga, Concettina
Ledda, Caterina
Rapisarda, Venerando
URI: http://hdl.handle.net/10201/124685
DOI: https://doi.org/10.14670/HH-18-116
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 10
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.34,nº10 (2019)

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