Por favor, use este identificador para citar o enlazar este ítem: DOI: 10.14670/HH-18-119

Título: Comparison of functional glycans between cancer stem cells and normal stem cells
Fecha de publicación: 2019
Editorial: Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, Vol.34, nº9, (2019)
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Cancer stem cell
Pluripotent stem cell
Tissue stem cell
Signaling pathway
Glycans
Resumen: Cancer stem cells (CSCs) are a small group of cells within a tumor that preserve stemness and enhance regrowth of cancer cells. CSCs have important implications in resistance to conventional therapies and tumor relapse, although their detailed properties remain unknown. Thus, CSCs represent promising targets to improve cancer treatment. So far, a number of cell surface markers containing glycans have been exploited to identify and isolate CSCs. Cell surface glycans are well-known markers for specific cell types and also play important cellular roles, such as regulation of cell signaling. In normal stem cells, including embryonic and tissue stem cells, glycan markers in an undifferentiated state have been identified. These markers are mostly known to regulate signaling pathways required for maintenance of stemness. In contrast, CSC-specific glycans have not been well characterized yet. In this review, we summarize functional commonalities between CSCs and normal stem cells in glycan-mediated signaling pathways. Identification of CSC-specific glycans may lead to early diagnosis and radical treatment of cancer.
Autor/es principal/es: Sasaki, Norihiko
Itakura, Yoko
Gomi, Fujiya
Hirano, Kazumi
Toyoda, Masashi
Ishiwata, Toshiyuki
URI: http://hdl.handle.net/10201/122227
DOI: DOI: 10.14670/HH-18-119
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 13
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.34, nº9 (2019)

Ficheros en este ítem:
Fichero Descripción TamañoFormato 
Sasaki-34-995-1007-2019.pdf1,14 MBAdobe PDFVista previa
Visualizar/Abrir


Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons Creative Commons