Disruption of mitochondrial homeostasis in chronic kidney disease: a mini-review

Abstract

Chronic kidney disease (CKD) is recognized as a worldwide health problem. Progression of CKD may lead to many serious complications, which are associated with increased morbidity and mortality. Presently, there is no satisfactory treatment. Thus, targeted therapies are urgently needed. The kidneys are second to the heart in terms of mitochondrial abundance and oxygen consumption. Thus, it is not surprising that mitochondrial homeostasis is absolutely essential for the normal function of the kidney. In fact, a number of reports indicate that mitochondria are involved in the progression of CKD. In this review, we summarize our current knowledge on mitochondrial homeostasis in CKD. We also provide an update on recent developments in the field of mitochondria-targeting therapeutic approaches against CKD