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DOI: 10.14670/HH-18-065
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Título: | Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina |
Fecha de publicación: | 2019 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.34, nº6, (2019) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Retina Neural stem cells Melatonin Cell proliferation Nestin expression |
Resumen: | Although melatonin has been shown to exhibit a wide variety of biological functions, its effects on promoting self-renewal in retinal stem cells remain unknown. We found that melatonin can significantly increase proliferation and enhance expression of a stem cell marker, nestin, in retinal neural stem cells (NSCs) via melatonin receptor 1 (MT1). The ERK pathway inhibitor SCH772984 and TGF-β pathway inhibitor SB431542 were used to study the melatonin-mediated molecular mechanisms of cell proliferation in NSCs. The results revealed a novel molecular mechanism of melatonin promotion of self-renewal of NSCs in which a chain reaction in the ERK and TGF-β/Smad pathways promotes self-renewal and transcription of nestin. In addition, dual-luciferase assays revealed that Smad4 directly regulated nestin transcription after melatonin treatment in NSCs. These findings revealed novel mechanisms through which the ERK pathway cooperates with the Smad pathway to regulate self-renewal in NSCs to enhance nestin expression. |
Autor/es principal/es: | Gao, Yuhua Ma, Li Bai, Chunyu Zhang, Xiangyang Yang, Wancai |
URI: | http://hdl.handle.net/10201/122005 |
DOI: | DOI: 10.14670/HH-18-065 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.34, nº6 (2019) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Gao-34-645-654-2019.pdf | 7,5 MB | Adobe PDF | Visualizar/Abrir |
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