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DOI: 10.14670/HH-18-087
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Título: | Striated-for-smooth muscle replacement in the developing mouse esophagus |
Fecha de publicación: | 2019 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.34, nº5, (2019) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Esophagus Myogenesis Myogenic regulatory factors cDNA microarrays |
Resumen: | The esophagus is a muscular tube which transports swallowed content from the oral cavity and the pharynx to the stomach. Early in mouse development, an entire layer of the esophagus, the muscularis externa, consists of differentiated smooth muscle cells. Starting shortly after mid-gestation till about two weeks after birth, the muscularis externa almost entirely consists of striated muscle. This proximal-to-distal replacement of smooth muscle by the striated muscle depends on a number of factors. To identify the nature of the hypothetical “proximal” (mainly striated muscle originating) and “distal” (mainly smooth muscle originating) signals that govern the striated-for-smooth muscle replacement, we compared the esophagus of Myf5:MyoD null fetuses completely lacking striated muscle to the normal control using cDNA microarray analysis, followed by a comprehensive database search. Here we provide an insight into the nature of “proximal” and “distal” signals that govern the striated-for-smooth muscle replacement in the esophagus. |
Autor/es principal/es: | Baguma Nibasheka, Mark Fracassi, Anna Costain, Willard J. Moreno, Sandra Kablar, Boris |
URI: | http://hdl.handle.net/10201/121524 |
DOI: | DOI: 10.14670/HH-18-087 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.34, nº5 (2019) |
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Fichero | Descripción | Tamaño | Formato | |
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Baguma-Nibasheka-34-457-467-2019.pdf | 204,17 kB | Adobe PDF | ![]() Visualizar/Abrir |
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