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DOI: 10.14670/HH-18-033
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Lacina, Lukáš | - |
dc.contributor.author | Brábek, Jan | - |
dc.contributor.author | Král, Vladimír | - |
dc.contributor.author | Kodet, Ondřej | - |
dc.contributor.author | Smetana Jr, Karel | - |
dc.date.accessioned | 2022-06-08T08:13:38Z | - |
dc.date.available | 2022-06-08T08:13:38Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Histology and Histopathology, Vol.34, nº2, (2019) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/121064 | - |
dc.description.abstract | Interleukin-6 is a multifaceted cytokine, usually reported as a pro-inflammatory molecule. However, certain anti-inflammatory activities were also attributed to IL-6. The levels of IL-6 in serum as well as in other biological fluids are elevated in an agedependent manner. Notably, it is consistently reported also as a key feature of the senescence-associated secretory phenotype. In the elderly, this cytokine participates in the initiation of catabolism resulting in, e.g. sarcopenia. It can cross the blood-brain barrier, and so it is in causal association with, e.g. depression, bipolar disorder, schizophrenia, and anorexia. In the cancer patient, IL-6 is produced by cancer and stromal cells and actively participates in their crosstalk. IL-6 supports tumour growth and metastasising in terminal patients, and it significantly engages in cancer cachexia (including anorexia) and depression associated with malignancy. The pharmacological treatment impairing IL-6 signalling represents a potential mechanism of antitumour therapy targeting cancer growth, metastatic spread, metabolic deterioration and terminal cachexia in patients. | es |
dc.format | application/pdf | es |
dc.format.extent | 12 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cancer microenvironment | es |
dc.subject | Cytokine | es |
dc.subject | Interleukin-6 | es |
dc.subject | Cancer | es |
dc.subject | Cachexia | es |
dc.subject | Anorexia | es |
dc.subject | Depression | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Interleukin-6: a molecule with complex biological impact in cancer | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-18-033 | - |
Aparece en las colecciones: | Vol.34, nº2 (2019) |
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Fichero | Descripción | Tamaño | Formato | |
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Lacina-34-125-136-2019.pdf | 1,69 MB | Adobe PDF | Visualizar/Abrir |
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