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DOI: 10.14670/HH-18-027
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Maounis, Nicoletta F. | - |
dc.contributor.author | Dráberová, Eduarda | - |
dc.contributor.author | Trakas, Nikos | - |
dc.contributor.author | Chorti, María | - |
dc.contributor.author | Riga, Dimitra | - |
dc.contributor.author | Tzannis, Kimon | - |
dc.contributor.author | Kanakis, Meletis | - |
dc.contributor.author | Voralu, Kirtanaa | - |
dc.contributor.author | Ellina, Eleni | - |
dc.contributor.author | Mahera, Eleni | - |
dc.contributor.author | Demonakou, Maria | - |
dc.contributor.author | Lioulias, Achilleas | - |
dc.contributor.author | Dráber, Pavel | - |
dc.contributor.author | Katsetos, Christos D. | - |
dc.date.accessioned | 2022-06-06T08:54:27Z | - |
dc.date.available | 2022-06-06T08:54:27Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Histology and Histopathology, Vol.34, nº1, (2019) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/120963 | - |
dc.description.abstract | Introduction. It has been reported that overexpression and altered compartmentalization of γtubulin may contribute to tumorigenesis and tumor aggressiveness in a variety of human malignancies. We have shown that γ-tubulin expression and cellular distribution pattern is also altered in non-small cell lung cancer (NSCLC) (Histol. Histopathol. 2012; 27: 1183- 1194). In the present study we examined the relationship between γ-tubulin expression and patient overall survival (OS). Material and methods. Immunohistochemistry was performed, with well-characterized anti-γ-tubulin antibodies, on 109 formalin-fixed, paraffin-embedded NSCLC specimens (p-TNM stage IIII). γ-Tubulin labeling indexes (LIs) were determined, and the association of γ-tubulin expression with clinicopathological parameters was evaluated. To analyze OS rates according to γ-tubulin LIs, patients were categorized into three groups: those with low (0- 30%), intermediate (31-69%) or high (70-100%) γtubulin LI. Association of clinicopathological parameters and γ-tubulin with survival were examined using univariate and multivariate Cox regression analysis. Results. No statistically significant association was seen between γ-tubulin overexpression and histological type, tumor differentiation, p-TNM stage and adenocarcinoma subtyping. Longer survival was observed in the high γtubulin LI group of patients with p-TNM stages II+III when compared to intermediate or low γ-tubulin LI groups, but the difference was not statistically significant (p=0.066). On the other hand, when combined low and intermediate γ-tubulin LI groups (p-TNM stages II+III) where compared to high γ-tubulin LI group, statistically significant longer survival was observed in high γtubulin group (p=0.021). Conclusion. Our findings suggest that level of γ-tubulin expression may have an impact on patient survival at more advanced NSCLC stages. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Gamma-tubulin | es |
dc.subject | Immunohistochemistry | es |
dc.subject | Non-small cell lung cancer | es |
dc.subject | Survival | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Expression of γ-tubulin in non-small cell lung cancer and effect on patient survival | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-18-027 | - |
Aparece en las colecciones: | Vol.34, nº1 (2019) |
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Maounis-34-81-90-2019.pdf | 26,27 MB | Adobe PDF | Visualizar/Abrir |
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