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DOI: 10.14670/HH-18-003
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Título: | Interplay between metalloproteinases and cell signalling in blood brain barrier integrity |
Fecha de publicación: | 2018 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.33, nº12, (2018) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Metalloproteinases Metzincins Bloodbrain barrier Signalling mechanisms Neuroinflammation |
Resumen: | The Blood-Brain Barrier (BBB) is a highly specialised interface separating the Central Nervous System (CNS) from circulating blood. Dysregulation of the BBB is a key early event in pathological conditions such as inflammation, in which the entry of activated leukocytes into the CNS is facilitated by BBB breakdown. The metzincin family of metalloproteinases (MPs) is one of the major contributors to BBB permeability as they cleave endothelial cell-cell contacts and underlying basal lamina components. However, the mechanisms by which MPs regulate BBB integrity has not yet been fully elucidated. The aim of this review is to provide an overview of pathways by which MPs could regulate the BBB in the context of neuroinflammation. |
Autor/es principal/es: | Pla Navarro, Irene Bevan, Damon Hajihosseini, Mohammad K. Lee, Martin Gavrilovic, Jelena |
URI: | http://hdl.handle.net/10201/120690 |
DOI: | DOI: 10.14670/HH-18-003 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 18 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.33,nº12 (2018) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Pla-Navarro-33-1253-1270-2018.pdf | 11,11 MB | Adobe PDF | Visualizar/Abrir |
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