Por favor, use este identificador para citar o enlazar este ítem: DOI: 10.14670/HH-18-003

Título: Interplay between metalloproteinases and cell signalling in blood brain barrier integrity
Fecha de publicación: 2018
Editorial: Universidad de Murcia. Departamento de Biología Celular e Histología
Cita bibliográfica: Histology and Histopathology, Vol.33, nº12, (2018)
ISSN: 1699-5848
0213-3911
Materias relacionadas: CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología
Palabras clave: Metalloproteinases
Metzincins
Bloodbrain barrier
Signalling mechanisms
Neuroinflammation
Resumen: The Blood-Brain Barrier (BBB) is a highly specialised interface separating the Central Nervous System (CNS) from circulating blood. Dysregulation of the BBB is a key early event in pathological conditions such as inflammation, in which the entry of activated leukocytes into the CNS is facilitated by BBB breakdown. The metzincin family of metalloproteinases (MPs) is one of the major contributors to BBB permeability as they cleave endothelial cell-cell contacts and underlying basal lamina components. However, the mechanisms by which MPs regulate BBB integrity has not yet been fully elucidated. The aim of this review is to provide an overview of pathways by which MPs could regulate the BBB in the context of neuroinflammation.
Autor/es principal/es: Pla Navarro, Irene
Bevan, Damon
Hajihosseini, Mohammad K.
Lee, Martin
Gavrilovic, Jelena
URI: http://hdl.handle.net/10201/120690
DOI: DOI: 10.14670/HH-18-003
Tipo de documento: info:eu-repo/semantics/article
Número páginas / Extensión: 18
Derechos: info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Aparece en las colecciones:Vol.33,nº12 (2018)

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