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DOI: 10.14670/HH-18-008
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Trovato, Francesca Maria | - |
dc.contributor.author | Castrogiovanni, Paola | - |
dc.contributor.author | Szychlinska, Marta Anna | - |
dc.contributor.author | Purrello, Francesco | - |
dc.contributor.author | Musumeci, Giuseppe | - |
dc.date.accessioned | 2022-05-30T08:48:21Z | - |
dc.date.available | 2022-05-30T08:48:21Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Histology and Histopathology, Vol.33, nº11, (2018) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/120606 | - |
dc.description.abstract | Background and Aim. Western high-fat diet is related to metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Decreased levels of Vitamin D (VitD) and IGF-1 and their mutual relationship were also reported. We aimed to evaluate whether different dietary profiles, containing or not VitD, may exert different effects on liver tissue. Methods. Twenty-eight male rats were fed for 10 weeks by different dietary regimens: R, regular diet; RDS and R-DR, regular diet with respectively VitD supplementation (DS) and restriction (DR); HFB-DS and HFB-DR (41% energy from fat), high fat (butter) diet; HFEVO-DS and HFEVO-DR (41% energy from fat), high fat (Extra-virgin olive oil-EVO) diet. Severity of NAFLD was assessed by NAFLD Activity Score. Collagen type I, IL-1beta, VitD-receptor, DKK-1 and IGF1 expressions were evaluated by immunohistochemistry. Results. All samples showed a NAS between 0 and 2 considered not diagnostic of steatohepatitis. Collagen I, although weakly expressed, was statistically greater in HFB-DS and HFB-DR groups. IL-1 was mostly expressed in rats fed with HFBs and HFEVOs and RDR, and almost absent in R and R-DS diets. IGF-1 and DKK-1 were reduced in HFBs and HFEVOs diets and in particular in DR groups. Conclusions. A short-term high-fat diet could damage liver tissue in terms of inflammation and collagen I deposition, setting the basis for the subsequent steatohepatitis, still not identifiable anatomopathologically. Vitamin D restriction increases inflammation and reduces the expression of IGF-1 in the liver, worsening the fat-induced changing. EVOO seems be protective against the collagen I production. | es |
dc.format | application/pdf | es |
dc.format.extent | 13 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Non-Alcoholic Fatty Liver Disease | es |
dc.subject | Western Diet | es |
dc.subject | Mediterranean Diet | es |
dc.subject | Histology | es |
dc.subject | Immunohistochemistry | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Early effects of high-fat diet, extra-virgin olive oil and vitamin D in a sedentary rat model of non-alcoholic fatty liver disease | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-18-008 | - |
Aparece en las colecciones: | Vol.33,nº11 (2018) |
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Trovato-33-1201-1213-2018.pdf | 15,13 MB | Adobe PDF | Visualizar/Abrir |
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