The expression of CD markers in solid tumors: Significance in metastasis and prognostic value

Abstract

Objective. The clusters of differentiations (CDs) are among the surface markers expressed on different cells in the body, which are involved in the communication of cells with each other and the induction of signaling. Moreover, the evaluation of the ectopic expression of these markers in solid tumors has led to the detection of disease in early stages. In this paper, we have examined the effect of CD markers expression on the function of cancer cells, as well as their importance as the diagnostic and prognostic factors for monitoring the progression of solid tumors. Materials and methods Relevant literature was identified by a PubMed search (1988-2017) of English the language papers using the terms “CD markers”, “diagnostic”, “prognostic”, “predictive marker” and “solid tumors.” Discussion. Finally, it can be stated that the evaluation of CDs is not only of diagnostic value at disease onset, but these markers can be used as prognostic and predictive markers to contribute to the treatment of disease and predict its relapse. Conclusion. Monitoring of tumors progression through CDs expressed on circulating tumor cells could be a new diagnostic and prognostic factor in the future.