Por favor, use este identificador para citar o enlazar este ítem:
DOI: 10.14670/HH-11-971
Twittear
Título: | Ageing-related aorta remodelling and calcification occur earlier and progress more severely in rats with spontaneous hypertension |
Fecha de publicación: | 2018 |
Editorial: | Universidad de Murcia. Departamento de Biología Celular e Histología |
Cita bibliográfica: | Histology and Histopathology, Vol.33, nº7, (2018) |
ISSN: | 1699-5848 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Hypertension Vascular ageing Vascular remodelling Vascular calcification |
Resumen: | The effects of hypertension on vascular remodelling, ageing and calcification are not fully understood. In this study, we monitored the dynamic changes of aorta remodelling, senescence and calcification in spontaneously hypertensive rats (SHRs) during ageing. Results. Vascular remodelling and senescence cells occurred in SHR aortas at 24 weeks. The calcium content and calcium deposition of the aorta increased in SHRs at 48 weeks. All of these changes became increasingly significant with ageing. In contrast, these pathologic changes appeared in Wistar-Kyoto (WKY) normotensive rats at a much later stage (72 weeks). These data showed that the ageing-related aorta remodelling, senescence and calcification in SHRs occurred earlier and progressed more severely than in WKY rats. Conclusion. Ageing-related vascular remodelling and calcification were accelerated and augmented in SHR aortas. |
Autor/es principal/es: | Shi, Xiaoyun Bai, Yajing Ke, Yilang Chen, Ruiqi Lin, Xiaohong Chen, Lianglong Hong, Huashan |
URI: | http://hdl.handle.net/10201/119695 |
DOI: | DOI: 10.14670/HH-11-971 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 10 |
Derechos: | info:eu-repo/semantics/openAccess Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
Aparece en las colecciones: | Vol.33, nº7 (2018) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Shi-33-727-736-2018.pdf | 9,36 MB | Adobe PDF | Visualizar/Abrir |
Este ítem está sujeto a una licencia Creative Commons Licencia Creative Commons