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DOI: 10.14670/HH-11-953
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Marfia, Giovanni | - |
dc.contributor.author | Pirola, Elena | - |
dc.contributor.author | Navone, Stefania Elena | - |
dc.contributor.author | Beretta, Matteo | - |
dc.contributor.author | Guarnaccia, Laura | - |
dc.contributor.author | Trombetta, Elena | - |
dc.contributor.author | Franzini, Andrea | - |
dc.contributor.author | Rampini, Paolo | - |
dc.contributor.author | Campanella, Rolando | - |
dc.date.accessioned | 2022-05-06T08:02:09Z | - |
dc.date.available | 2022-05-06T08:02:09Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | Histology and Histopathology, Vol.33, nº7, (2018) | es |
dc.identifier.issn | 1699-5848 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | http://hdl.handle.net/10201/119644 | - |
dc.description.abstract | A 36-year-old white man presented with sudden-onset headache and rapid deterioration of consciousness. Computer tomography revealed a right capsular intra-parenchimal hemorrhage with an intraventricular component; therefore, emergency surgery was performed. Once the hematoma was evacuated, the cause of the hemorrhage was identified as a tumor mass and it was resected. Histopathological and immunohistochemical examinations of the surgical specimen disclosed a diagnosis of atypical central neurocytoma. By using a protocol recently set up in our laboratory, we succeeded in isolating and propagating, for the first time, human endothelial cells from central neurocytoma (CN-ECs). Different analyses revealed that isolated CNECs consist of a pure endothelial cell population, with the expression of endothelial markers (CD31, CD309/VEGFR2, CD105, eNOS) and with angiogenic properties, such as the uptake of LDL. Moreover, CNECs spontaneously organize in a vascular-like structure. The goal of this case report is to stress the need for further studies focused on understanding the causes of the onset of an intra-parenchimal hemorrhage in the presence of an atypical central neurocytoma in order to tailor treatments to each single patient and achieve the best clinical outcome. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Universidad de Murcia. Departamento de Biología Celular e Histología | es |
dc.relation | Sin financiación externa a la Universidad | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Brain tumor | es |
dc.subject | Neurocytoma | es |
dc.subject | Spontaneous intracranial hemorrhage | es |
dc.subject | Endothelial cells | es |
dc.subject | Glioblastoma | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Spontaneous intracerebral hemorrhage as presentation of atypical central neurocytoma: the role of angiogenesis through the characterization of tumor endothelial cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | DOI: 10.14670/HH-11-953 | - |
Aparece en las colecciones: | Vol.33, nº7 (2018) |
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Fichero | Descripción | Tamaño | Formato | |
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Marfia-33-665-672-2018.pdf | 6,63 MB | Adobe PDF | Visualizar/Abrir |
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